Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies

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dc.contributor.authorValdes, G
dc.contributor.authorNeves, LAA
dc.contributor.authorAnton, L
dc.contributor.authorCorthorn, J
dc.contributor.authorChacon, C
dc.contributor.authorGermain, AM
dc.contributor.authorMerrill, DC
dc.contributor.authorFerrario, CM
dc.contributor.authorSarao, R
dc.contributor.authorPenninger, J
dc.contributor.authorBrosnihan, KB
dc.date.accessioned2024-01-10T12:38:23Z
dc.date.available2024-01-10T12:38:23Z
dc.date.issued2006
dc.description.abstractThis work was designed to study the expression of the vasodilator peptide angiotensin-(1-7) [Ang-(1-7)] and its generating enzyme (ACE2) in the uteroplacental interface. Placentas were obtained from 11 early pregnancy failures (5 miscarriages and 6 ectopic pregnancies), 15 normotensive, and 10 preeclamptic gestations. In placental villi, the main sites of immunocytochemical expression of Ang-(1-7) and ACE2 were the syncytiotrophoblast, cytotrophoblast, endothelium and vascular smooth muscle of primary and secondary villi. Syncitial Ang-(1-7) expression in samples obtained from miscarriages and ectopic pregnancies was increased compared to normal term pregnancy [2.0 (2.0-2.25 for the 25 and 75% interquartile range) vs 1.3 (1.0-1.9), p < 0.01]. In the maternal stroma, Ang-(1-7) and ACE2 were expressed in the invading and intravascular trophoblast and in decidual cells in all 3 groups. Ang-(1-7) and ACE2 staining was also found in arterial and venous endothelium and smooth muscle of the umbilical cord. The expression of Ang-(1-7) and ACE2 was similar in samples obtained from normal term or preeclamptic pregnancies, except for increased expression of ACE2 in umbilical arterial endothelium in preeclarmpsia [0.5 (0.5-0.8) vs 0.0 (0.0-0.0), p < 0.01]. The uteroplacental location of Ang-(1-7) and ACE2 in pregnancy suggests an autocrine function of Ang-(1-7) in the vasoactive regulation that characterizes placentation and established pregnancy. (c) 2005 Elsevier Ltd. All rights reserved.
dc.description.funderNHLBI NIH HHS
dc.description.funderNICHD NIH HHS
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital05-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.placenta.2005.02.015
dc.identifier.eissn1532-3102
dc.identifier.issn0143-4004
dc.identifier.pubmedidMEDLINE:16338465
dc.identifier.urihttps://doi.org/10.1016/j.placenta.2005.02.015
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77035
dc.identifier.wosidWOS:000234728000011
dc.information.autorucMedicina;Valdés G;S/I;98654
dc.issue.numero2-3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final207
dc.pagina.inicio200
dc.publisherW B SAUNDERS CO LTD
dc.revistaPLACENTA
dc.rightsacceso restringido
dc.subjecthypertension
dc.subjectpregnancy
dc.subjectangiotensin-(1-7)
dc.subjectpreeclampsia
dc.subjectrenin angiotensin system
dc.subjectangiotensin converting enzyme 2
dc.subjectENDOTHELIAL GROWTH-FACTOR
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectENZYME-RELATED CARBOXYPEPTIDASE
dc.subjectCONVERTING ENZYME
dc.subjectTISSUE KALLIKREIN
dc.subjectHYPERTENSIVE-RATS
dc.subjectOPPOSING ACTIONS
dc.subjectLATE-GESTATION
dc.subjectBRADYKININ
dc.subjectLOCALIZATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDistribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies
dc.typeartículo
dc.volumen27
sipa.codpersvinculados98654
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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