Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure

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dc.contributor.authorVillanueva, Sandra
dc.contributor.authorEscobar, Pia
dc.contributor.authorJacubovsky, Ioram
dc.contributor.authorIrarrazabal, Carlos
dc.contributor.authorCarreno, Juan E.
dc.contributor.authorErpel, Jose M.
dc.contributor.authorCespedes, Carlos
dc.contributor.authorGonzalez, Alexis A.
dc.contributor.authorVio, Carlos P.
dc.contributor.authorVelarde, Victoria
dc.date.accessioned2024-01-10T13:47:18Z
dc.date.available2024-01-10T13:47:18Z
dc.date.issued2012
dc.description.abstractAcute renal failure (ARF) can be caused by injuries that induce tissue hypoxia, which in turn can trigger adaptive or inflammatory responses. We previously showed the participation of basic fibroblast growth factor (FGF-2) in renal repair. Based on this, the aim of this study was to analyze the effect of FGF-2 signaling pathway manipulation at hypoxia-induced protein levels, as well as in key proteins from the vasoactive systems of the kidney. We injected rat kidneys with FGF-2 recombinant protein (r-FGF) or FGF-2 receptor antisense oligonucleotide (FGFR2-ASO) after bilateral ischemia, and evaluated the presence of iNOS, EPO and HO-1, in representation of hypoxia-induced proteins, as well as COX-2, renin, kallikrein, and B2KR, in representation of the vasoactive systems of the kidney. A reduction in iNOS, HO-1, EPO, renin, kallikrein, B2KR, and in renal damage was observed in animals treated with r-FGF. The opposite effect was found with FGF-2 receptor down-regulation. In contrast, COX-2 protein levels were higher in kidneys treated with r-FGF and lower in those that received FGFR2-ASO, as compared to saline treated kidneys. These results suggest that the protective role of FGF-2 in the pathogenesis of ARF induced by I/R is a complex process, through which a differential regulation of metabolic pathways takes place.
dc.description.funderFondecyt
dc.description.funderAnillo Act71
dc.description.funderProyecto
dc.description.funderPrograma de Financiamiento Basal PFB
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0716-97602012000100007
dc.identifier.eissn0717-6287
dc.identifier.issn0716-9760
dc.identifier.pubmedidMEDLINE:22688984
dc.identifier.urihttps://doi.org/10.4067/S0716-97602012000100007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79255
dc.identifier.wosidWOS:000302674500007
dc.information.autorucCiencias Biológicas;Cespedes C ;S/I;116908
dc.information.autorucCiencias Biológicas;Erpel J;S/I;188882
dc.information.autorucCiencias Biológicas;Gonzalez A;S/I;11971
dc.information.autorucCiencias Biológicas;Velarde V;S/I;55362
dc.information.autorucCiencias Biológicas;Vio C;S/I;99575
dc.issue.numero1
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final60
dc.pagina.inicio51
dc.publisherSOC BIOLGIA CHILE
dc.revistaBIOLOGICAL RESEARCH
dc.rightsregistro bibliográfico
dc.subjectARF
dc.subjectCOX-2
dc.subjectFGF-2
dc.subjectkidney regeneration
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectTHICK ASCENDING LIMB
dc.subjectHEME OXYGENASE-1 GENE
dc.subjectENDOTHELIAL-CELLS
dc.subjectKALLIKREIN-KININ
dc.subjectRAT-KIDNEY
dc.subjectNEPHROGENIC PROTEINS
dc.subjectREPERFUSION INJURY
dc.subjectRENIN-ANGIOTENSIN
dc.subjectEXPRESSION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure
dc.typeartículo
dc.volumen45
sipa.codpersvinculados116908
sipa.codpersvinculados188882
sipa.codpersvinculados11971
sipa.codpersvinculados55362
sipa.codpersvinculados99575
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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