Interplay between Epstein-Barr virus infection and environmental xenobiotic exposure in cancer

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dc.contributor.authorAguayo González, Francisco
dc.contributor.authorBoccardo, Enrique
dc.contributor.authorCorvalán R., Alejandro
dc.contributor.authorCalaf, Gloria M.
dc.contributor.authorBlanco, Rancés
dc.date.accessioned2021-07-06T15:29:14Z
dc.date.available2021-07-06T15:29:14Z
dc.date.issued2021
dc.date.updated2021-07-04T00:03:15Z
dc.description.abstractAbstract Epstein-Barr virus (EBV) is a herpesvirus associated with lymphoid and epithelial malignancies. Both B cells and epithelial cells are susceptible and permissive to EBV infection. However, considering that 90% of the human population is persistently EBV-infected, with a minority of them developing cancer, additional factors are necessary for tumor development. Xenobiotics such as tobacco smoke (TS) components, pollutants, pesticides, and food chemicals have been suggested as cofactors involved in EBV-associated cancers. In this review, the suggested mechanisms by which xenobiotics cooperate with EBV for carcinogenesis are discussed. Additionally, a model is proposed in which xenobiotics, which promote oxidative stress (OS) and DNA damage, regulate EBV replication, promoting either the maintenance of viral genomes or lytic activation, ultimately leading to cancer. Interactions between EBV and xenobiotics represent an opportunity to identify mechanisms by which this virus is involved in carcinogenesis and may, in turn, suggest both prevention and control strategies for EBV-associated cancers.
dc.format.extent15 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationInfectious Agents and Cancer. 2021 Jun 30;16(1):50
dc.identifier.doi10.1186/s13027-021-00391-2
dc.identifier.urihttps://doi.org/10.1186/s13027-021-00391-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/60972
dc.information.autorucEscuela de Medicina ; Corvalán R., Alejandro ; 0000-0001-5492-3853 ; 63885
dc.issue.numeroNo. 50
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final15
dc.pagina.inicio1
dc.revistaInfectious Agents and Canceres_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectEpstein-Barr viruses_ES
dc.subjectEnvironmentales_ES
dc.subjectCanceres_ES
dc.subject.ddc614.5999
dc.subject.deweyMedicina y saludes_ES
dc.titleInterplay between Epstein-Barr virus infection and environmental xenobiotic exposure in canceres_ES
dc.typeartículo
dc.volumenVol. 16
sipa.codpersvinculados63885
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