Intra-arterial thrombolysis in locked-in syndrome. Report of two cases

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dc.contributor.authorMellado, P
dc.contributor.authorSandoval, P
dc.contributor.authorTevah, J
dc.contributor.authorHuete, I
dc.contributor.authorCastillo, L
dc.date.accessioned2024-01-10T12:39:50Z
dc.date.available2024-01-10T12:39:50Z
dc.date.issued2004
dc.description.abstractLocked-in syndrome is a dramatic clinical condition, the patient is can listen. and breath, but is unable to move any muscle, conserving only The vertical eye movements. The most common cause of locked-in syndrome is the thrombosis of the basilar artery and commonly leads to death, frequently due to pneumonia. Intravenous and intra arterial thrombolysis have been used successfully in a selective group of patients with ischemic stroke. There is only one report of two patients with locked-in syndrome who were treated successfuly with intra arterial thrombolysis. Other authors, based in their experiences, do not recommended this treatment. We report two female patients aged 63 and 26 years, with Locked-in syndrome due to a basilar thrombosis who were treated successfully with intra arterial thrombolysis using ecombinant tissue plasminogen activator (r-TPA). The lapses between the onset of the symptoms and thrombolysis were 5 and 8 hours respectively. A complete recanalization was obtained in both patients during the thrombolysis. One year after, the first patient has only a moderate ataxia, walking with assistance and the other has a normal neurological examination (Rev Med Chile 2004; 132: 357-60).
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:15376574
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77241
dc.identifier.wosidWOS:000228070100012
dc.information.autorucMedicina;Huete I;S/I;98812
dc.issue.numero3
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final360
dc.pagina.inicio357
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectlocked-in syndrome
dc.subjectplasminogen activators
dc.subjectthrombolytic therapy
dc.subjectvertebrobasilar insufficiency
dc.subjectBASILAR ARTERY-OCCLUSION
dc.subjectACUTE ISCHEMIC-STROKE
dc.subjectVERTEBROBASILAR OCCLUSION
dc.subjectTHERAPY
dc.subjectFIBRINOLYSIS
dc.subjectANGIOPLASTY
dc.subjectTHROMBOSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIntra-arterial thrombolysis in locked-in syndrome. Report of two cases
dc.typeartículo
dc.volumen132
sipa.codpersvinculados98812
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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