Efects of eccentric, concentric and eccentric/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicentre randomised trial

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dc.article.number278
dc.contributor.authorPeñailillo, Luis
dc.contributor.authorValladares-Ide, Denisse
dc.contributor.authorJannas-Velas, Sebastián
dc.contributor.authorFlores-Opazo, Marcelo
dc.contributor.authorJalón, Mauricio
dc.contributor.authorMendoza, Laura
dc.contributor.authorNuñez, Ingrid
dc.contributor.authorDíaz Patiño, Orlando
dc.date.accessioned2022-07-27T13:30:15Z
dc.date.available2022-07-27T13:30:15Z
dc.date.issued2022
dc.date.updated2022-07-24T00:03:34Z
dc.description.abstractBackground: Chronic obstructive pulmonary disease (COPD) is the third cause of death worldwide. COPD is char‑acterised by dyspnoea, limited exercise tolerance, and muscle dysfunction. Muscle dysfunction has been linked to dysregulation between muscle protein synthesis, myogenesis and degradation mechanisms. Conventional concentric cycling has been shown to improve several clinical outcomes and reduce muscle wasting in COPD patients. Eccentric cycling is a less explored exercise modality that allows higher training workloads imposing lower cardio-metabolic demand during exercise, which has shown to induce greater muscle mass and strength gains after training. Interestingly, the combination of eccentric and concentric cycling training has scarcely been explored. The molecular adaptations of skeletal muscle after exercise interventions in COPD have shown equivocal results. The mechanisms of muscle wasting in COPD and whether it can be reversed by exercise training are unclear. Therefore, this study aims two-fold: (1) to compare the efects of 12 weeks of eccentric (ECC), concentric (CONC), and combined eccentric/concentric (ECC/CONC) cycling training on muscle mass and function, cardiometabolic health, physical activity levels and quality of life in severe COPD patients; and (2) to examine the molecular adaptations regulating muscle growth after training, and whether they occur similarly in specifc muscle fbres (i.e., I, IIa and IIx). Methods: Study 1 will compare the efects of 12 weeks of CONC, ECC, versus ECC/CONC training on muscle mass and function, cardiometabolic health, levels of physical activity and quality of life of severe COPD patients using a multicentre randomised trial. Study 2 will investigate the efects of these training modalities on the molecular adaptations regulating muscle protein synthesis, myogenesis and muscle degradation in a subgroup of patients from Study 1. Changes in muscle fbres morphology, protein content, genes, and microRNA expression involved in skeletal muscle growth will be analysed in specifc fbre-type pools. Discussion: We aim to demonstrate that a combination of eccentric and concentric exercise could maximise the improvements in clinical outcomes and may be ideal for COPD patients. We also expect to unravel the molecular mechanisms underpinning muscle mass regulation after training in severe COPD patients.
dc.format.extent11 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationBMC Pulmonary Medicine. 2022 Jul 19;22(1):278
dc.identifier.doi10.1186/s12890-022-02061-4
dc.identifier.urihttps://doi.org/10.1186/s12890-022-02061-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/64461
dc.information.autorucEscuela de medicina ; Nuñez, Ingrid ; S/I ; 1213951
dc.information.autorucEscuela de medicina ; Díaz Patiño, Orlando ; 0000-0002-5860-1381 ; 78564
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.revistaBMC Pulmonary Medicine
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectChronic obstructive pulmonary diseasees_ES
dc.subjectAerobic traininges_ES
dc.subjectRespiratory diseasees_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEfects of eccentric, concentric and eccentric/concentric training on muscle function and mass, functional performance, cardiometabolic health, quality of life and molecular adaptations of skeletal muscle in COPD patients: a multicentre randomised triales_ES
dc.typeartículo
dc.volumen22
sipa.codpersvinculados1213951
sipa.codpersvinculados78564
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