Melanocortin-3 receptor gene variants: Association with childhood obesity and eating behavior in Chilean families

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dc.contributor.authorObregon, A. M.
dc.contributor.authorAmador, P.
dc.contributor.authorValladares, M.
dc.contributor.authorWeisstaub, G.
dc.contributor.authorBurrows, R.
dc.contributor.authorSantos, J. L.
dc.date.accessioned2024-01-10T12:40:17Z
dc.date.available2024-01-10T12:40:17Z
dc.date.issued2010
dc.description.abstractObjective: To evaluate the association between melanocortin-3 receptor common genetic polymorphisms with childhood obesity and eating behavior in Chilean families.
dc.description.abstractMethods: Two hundred twenty-nine obese children (6-12 y old, body mass index >95th percentile of Centers for Disease Control and Prevention/National Center for Health Statistics, 2000) and 270 parents were selected. Genotypes for MC3R genetic markers -239A > G, 17C > A (Thr6Lys), 241 G > A (Val81Ile), +2138InsCAGACC, and microsatellite D20s32e were determined. Eating behavior scores were computed using the Child Eating Behavior Questionnaire and a shorter version of the Three Factor Eating Questionnaire adapted for evaluating eating inclinations in children. Genotype-obesity associations were assessed by the Transmission Disequilibrium Test. Non-parametric tests were used to compare eating behavior scores across study groups.
dc.description.abstractResults: Allelic frequencies of -239 G, 17A, 241A, and +2138InsCAGACC were estimated as 4.5%, 5.9%, 5.6%, and 17.6%, respectively, in obese children. The Transmission Disequilibrium Test in case-parent trios revealed no significant associations between childhood obesity and genetic markers, including the microsatellite D20s32e. In girls, we found significantly higher scores of the emotional eating subscale in Carriers of the +2138InsCAGACC compared with non-carriers (P=0.04). In boys, carriers of 17A and 241A showed lower scores for the emotional eating subscale (P=0.01), whereas carriers of +2138InsCAGACC showed significantly lower scores for the enjoyment of food subscale compared with non-carriers (P=0.04).
dc.description.abstractConclusions: There is not sufficient evidence to support the contribution for common melanocortin-3 receptor variants in childhood obesity. However, our results are concordant for a role of melanocortin-3 receptor variants in some dimensions of eating behavior such as emotional eating and enjoyment of food. (C) 2010 Elsevier Inc. All rights reserved.
dc.description.funderFONDECYT, Chile
dc.fechaingreso.objetodigital03-04-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.nut.2009.07.005
dc.identifier.eissn1873-1244
dc.identifier.issn0899-9007
dc.identifier.pubmedidMEDLINE:20144537
dc.identifier.urihttps://doi.org/10.1016/j.nut.2009.07.005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77293
dc.identifier.wosidWOS:000279455100013
dc.information.autorucMedicina;Santos JL;S/I;1005923
dc.issue.numero7-8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final765
dc.pagina.inicio760
dc.publisherELSEVIER SCIENCE INC
dc.revistaNUTRITION
dc.rightsacceso restringido
dc.subjectChildhood obesity
dc.subjectEating behavior
dc.subjectMelanocortin receptor
dc.subjectGenetic
dc.subjectFUNCTIONAL-CHARACTERIZATION
dc.subjectLINKAGE DISEQUILIBRIUM
dc.subjectBODY-WEIGHT
dc.subjectFOOD-INTAKE
dc.subjectFAT MASS
dc.subjectMUTATIONS
dc.subjectAPPETITE
dc.subjectCHILDREN
dc.subjectPOPULATION
dc.subjectSUBTYPES
dc.subject.ods02 Zero Hunger
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa02 Hambre cero
dc.subject.odspa03 Salud y bienestar
dc.titleMelanocortin-3 receptor gene variants: Association with childhood obesity and eating behavior in Chilean families
dc.typeartículo
dc.volumen26
sipa.codpersvinculados1005923
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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