Health and economic efects on patients with type 2 diabetes mellitus in the long run: predictions for the Chilean population

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dc.article.number155
dc.contributor.authorEspinoza Sepúlveda, Manuel Antonio
dc.contributor.authorAbbott, Tomás
dc.contributor.authorPassi, Álvaro
dc.contributor.authorBalmaceda, Carlos
dc.date.accessioned2022-11-14T16:04:31Z
dc.date.available2022-11-14T16:04:31Z
dc.date.issued2022
dc.date.updated2022-10-30T00:02:14Z
dc.description.abstractBackground: Diabetes is associated to a high financial and disease burden, explaining a large proportion of expenditure of the health system in one year. The purpose of this study was to estimate long-term costs and health outcomes of recently diagnosed patients with type 2 diabetes in Chile. Methods: Cost and consequence study based on mathematical discrete event simulation (DES) model. We modelled expected costs (USD) and quality-adjusted life-years (QALYs) from diagnosis to death (or the age of 95) of a hypothetical cohort of 100,000 incident cases, simulated based on the Chilean National Health Survey 2018. The incidence of twelve complications was estimated assuming the hazard functions provided by the United Kingdom Prospective Diabetes Study. We explore heterogeneity across patients based on their baseline risk covariates and their impact on costs and QALYs. Results: The expected cost and QALY of a recently diagnosed type 2 diabetes patient in Chile were USD 8660 and 12.44 QALYs. Both costs and QALYs were independently determined by baseline risk and the patient's life expectancy from the diagnosis. Length of life since diagnosis showed the major impact on costs (5.2% increase for every additional year). Myocardial infarction was the most frequent complication (47.4%) and the most frequent cause of death. Conclusion Diabetes type 2 determines a significant expenditure of the health system and substantial health losses. Although the control of cardiovascular risk factors and the metabolic control of the disease, both have an important impact on costs and outcomes, the main impact is achieved by postponing the age of onset of the disease.
dc.format.extent8 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationDiabetology & Metabolic Syndrome. 2022 Oct 26;14(1):155
dc.identifier.doi10.1186/s13098-022-00928-4
dc.identifier.urihttps://doi.org/10.1186/s13098-022-00928-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/65572
dc.information.autorucEscuela de medicina ; Espinoza Sepúlveda, Manuel Antonio ; 0000-0001-9564-9512 ; 10720
dc.information.autorucEscuela de medicina ; Abbott, Tomás ; S/I ; 203717
dc.information.autorucEscuela de medicina ; Passi, Álvaro ; S/I ; 155739
dc.information.autorucEscuela de medicina ; Balmaceda, Carlos ; S/I ; 169851
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final8
dc.pagina.inicio1
dc.revistaDiabetology & Metabolic Syndrome
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectDiabetes type 2es_ES
dc.subjectLong-termes_ES
dc.subjectCostses_ES
dc.subjectHealth outcomeses_ES
dc.subjectPopulation predictionses_ES
dc.subjectCardiovascular risk factorses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleHealth and economic efects on patients with type 2 diabetes mellitus in the long run: predictions for the Chilean populationes_ES
dc.typeartículo
dc.volumen14
sipa.codpersvinculados10720
sipa.codpersvinculados203717
sipa.codpersvinculados155739
sipa.codpersvinculados169851
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