Cortico-Striatal Oscillations Are Correlated to Motor Activity Levels in Both Physiological and Parkinsonian Conditions

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dc.catalogadorpva
dc.contributor.authorMoenne Vargas, Cristóbal Matías
dc.contributor.authorAstudillo Valenzuela, Carolina
dc.contributor.authorSkovgard, Katrine
dc.contributor.authorSalazar Reyes, Carolina A.
dc.contributor.authorBarrientos, Sebastián A.
dc.contributor.authorGarcía Núñez, Ximena P.
dc.contributor.authorCenci, M. Angela
dc.contributor.authorPetersson, Per
dc.contributor.authorFuentes Flores, Rómulo A.
dc.date.accessioned2021-07-28T16:25:42Z
dc.date.available2021-07-28T16:25:42Z
dc.date.issued2020
dc.description.abstractOscillatory neural activity in the cortico-basal ganglia-thalamocortical (CBGTC) loop is associated with the motor state of a subject, but also with the availability of modulatory neurotransmitters. For example, increased low-frequency oscillations in Parkinson's disease (PD) are related to decreased levels of dopamine and have been proposed as biomarkers to adapt and optimize therapeutic interventions, such as deep brain stimulation. Using neural oscillations as biomarkers require differentiating between changes in oscillatory patterns associated with parkinsonism vs. those related to a subject's motor state. To address this point, we studied the correlation between neural oscillatory activity in the motor cortex and striatum and varying degrees of motor activity under normal and parkinsonian conditions. Using rats with bilateral or unilateral 6-hydroxydopamine lesions as PD models, we correlated the motion index (MI)-a measure based on the physical acceleration of the head of rats-to the local field potential (LFP) oscillatory power in the 1-80 Hz range. In motor cortices and striata, we observed a robust correlation between the motion index and the oscillatory power in two main broad frequency ranges: a low-frequency range [5.0-26.5 Hz] was negatively correlated to motor activity, whereas a high-frequency range [35.0-79.9 Hz] was positively correlated. We observed these correlations in both normal and parkinsonian conditions. In addition to these general changes in broad-band power, we observed a more restricted narrow-band oscillation [25-40 Hz] in dopamine-denervated hemispheres. This oscillation, which seems to be selective to the parkinsonian state, showed a linear frequency dependence on the concurrent motor activity level. We conclude that, independently of the parkinsonian condition, changes in broad-band oscillatory activities of cortico-basal ganglia networks (including changes in the relative power of low- and high-frequency bands) are closely correlated to ongoing motions, most likely reflecting he operations of these neural circuits to control motor activity. Hence, biomarkers based on neural oscillations should focus on specific features, such as narrow frequency bands, to allow differentiation between parkinsonian states and physiological movement-dependent circuit modulation.
dc.fechaingreso.objetodigital2024-07-24
dc.format.extent11 páginas
dc.fuente.origenConveris
dc.identifier.doi10.3389/fnsys.2020.00056
dc.identifier.issn1662-5137
dc.identifier.pubmedid32903888
dc.identifier.urihttps://doi.org/10.3389/fnsys.2020.00056
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/61506
dc.identifier.wosidWOS:000566257400001
dc.information.autorucCiencias de la Salud ; Astudillo Valenzuela, Carolina Isabel ; S/I ; 1094590
dc.information.autorucDepartamento de Ciencias de la Salud; Moenne Vargas, Cristóbal Matías; 0000-0002-9524-2832; 140920
dc.information.autorucDepartamento de Ciencias de la Salud; Astudillo Valenzuela, Carolina; S/I; 1094590
dc.information.autorucFacultad de Ciencias Biológicas; Barrientos, Sebastián A.; S/I; 156073
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.publisherFrontiers Media SA
dc.revistaFrontiers in Systems Neuroscience
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCortex
dc.subjectStriatum
dc.subjectOscillations
dc.subjectLocal field potential
dc.subjectParkinsonian
dc.subjectMotor activity
dc.subjectAcceleration
dc.subjectBeta
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCortico-Striatal Oscillations Are Correlated to Motor Activity Levels in Both Physiological and Parkinsonian Conditionses_ES
dc.typeartículo
dc.volumenVol. 14
dc.volumen14
sipa.codpersvinculados1094590
sipa.codpersvinculados140920
sipa.codpersvinculados156073
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