Comparative study between conservative solutions with and without formaldehyde in human placenta

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dc.contributor.authorWolff, Daniel
dc.contributor.authorVilla, Pablo
dc.contributor.authorNeirreitter, Alejandra
dc.contributor.authorRuibal, Cecilia
dc.contributor.authorArmand Ugon, Gustavo
dc.contributor.authorSalgado, Guillermo
dc.contributor.authorCantin, Mario
dc.date.accessioned2024-01-10T13:11:51Z
dc.date.available2024-01-10T13:11:51Z
dc.date.issued2012
dc.description.abstractThe fixation and conservation techniques of anatomic material are commonly performed with solutions containing formaldehyde, given its low cost. These have several disadvantages such as the irritating odor, stiffness, discoloration of the structures, toxicity, carcinogenic, teratogenic and mutagenic risk for those who are exposed. Therefore it is desirable to use solutions without formaldehyde. The aim of this study was to compare 2 methods of anatomical conservation, one with formalin (Montevideo's solution) and one without formalin (Prives method) using the human placenta as an experimental organ model evaluating its macroscopic parameters. We used 46 human placentas from normal deliveries and term pregnancy. The placentas were separated into two groups (n=22 and n=24 respectively). The first group of placentas was perfused with formaldehyde solution and the second group in a solution without formaldehyde. Then both groups were immersed and maintained in their respective solutions for two weeks and then withdrawn leaving the air at room temperature for 2 weeks. Quantitative variables were analyzed for weight and diameter of each piece, and qualitative variables as consistency, color, odor and growth of micro/macro organisms were evaluated. Data collection was performed prior to washing at 14, 21 and 28 days. The results showed that conserved placentas with Prives method showed better conservation in relation to its diameter, consistency, color and less irritating odor in relation to placentas treated with formalin solution. In no case was growth of micro or macro organism. In conclusion, using advantageously at alternative solutions to formaldehyde, as the formula of Prives method, better preserved macroscopic characteristics of placentas without generating an irritating smell, stopping the decomposition process.
dc.fechaingreso.objetodigital2024-05-30
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0717-95022012000200013
dc.identifier.eissn0717-9367
dc.identifier.issn0717-9502
dc.identifier.urihttps://doi.org/10.4067/S0717-95022012000200013
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78106
dc.identifier.wosidWOS:000308261900013
dc.information.autorucMedicina;Salgado G;S/I;1008579
dc.issue.numero2
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final438
dc.pagina.inicio432
dc.publisherSOC CHILENA ANATOMIA
dc.revistaINTERNATIONAL JOURNAL OF MORPHOLOGY
dc.rightsacceso abierto
dc.subjectPlacenta
dc.subjectAnatomical techniques
dc.subjectFixative solution
dc.subjectFormaldehyde
dc.subjectFormaldehyde free
dc.subjectIDENTIFICATION
dc.subjectEXPOSURE
dc.subjectFIXATION
dc.subjectANATOMY
dc.subject.ods04 Quality Education
dc.subject.odspa04 Educación y calidad
dc.titleComparative study between conservative solutions with and without formaldehyde in human placenta
dc.typeartículo
dc.volumen30
sipa.codpersvinculados1008579
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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