Protocol of a Living systematic review: gloves for the prevention of COVID-19 in healthy population
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Date
2020
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Abstract
Objective: To determine the efficacy of the use of gloves in the prevention of COVID-19 disease in healthy population. Design: This is the protocol of a living systematic review. Data sources: We will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature and in a centralised repository in L·OVE (Living OVerview of Evidence).L·OVE is a platform that maps PICO questions to evidence from Epistemonikos database. In responseto the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it covers and customised to group all COVID-19 evidence in one place. The search will cover the period until the day before submission to a journal. Eligibility criteria for selecting studies and methods We adapted an already published common protocol for multiple parallel systematic reviews to the specificities of this question. We will include randomized trials evaluating the effect of use of gloves in healthy population to prevent COVID-19 disease. Randomised trials evaluating the effect of use of gloves during outbreaks caused by other coronaviruses, such as MERS-CoV and SARS-CoV, and non-randomised studies in COVID-19 will be searched in case no direct evidence from randomised trials is found, or if the direct evidence provides low- or very low-certainty for critical outcomes. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will perform random-effects meta-analyses and use GRADE to assess the certainty of the evidence for each outcome. A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit it if the conclusions change or there are substantial updates.
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Keywords
COVID-19, Severe acute respiratory syndrome coronavirus 2, Coronavirus Infections, Systematic review, Glove, Double-glove