Understanding weight gain at menopause

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dc.contributor.authorDavis, S. R.
dc.contributor.authorCastelo Branco, C.
dc.contributor.authorChedraui, P.
dc.contributor.authorLumsden, M. A.
dc.contributor.authorNappi, R. E.
dc.contributor.authorShah, D.
dc.contributor.authorVillaseca, P.
dc.contributor.authorInt Menopause Soc World Menopause
dc.date.accessioned2024-01-10T13:09:52Z
dc.date.available2024-01-10T13:09:52Z
dc.date.issued2012
dc.description.abstractObjective The aim of this review was to summarize the literature regarding the impact of the menopause transition on body weight and body composition.
dc.description.abstractMethods We conducted a search of the literature using Medline (Ovid, 1946-present) and PubMed (1966-2012) for English-language studies that included the following search terms: 'menopause', 'midlife', 'hormone therapy' or 'estrogen' combined with 'obesity', 'body weight' or 'body composition'.
dc.description.abstractResults Whereas weight gain per se cannot be attributed to the menopause transition, the change in the hormonal milieu at menopause is associated with an increase in total body fat and an increase in abdominal fat. Weight excess at midlife is not only associated with a heightened risk of cardiovascular and metabolic disease, but also impacts adversely on health-related quality of life and sexual function. Animal and human studies indicate that this tendency towards central abdominal fat accumulation is ameliorated by estrogen therapy. Studies mostly indicate a reduction in overall fat mass with estrogen and estrogen-progestin therapy, improved insulin sensitivity and a lower rate of development of type 2 diabetes.
dc.description.abstractConclusion The hormonal changes across the perimenopause substantially contribute to increased abdominal obesity which leads to additional physical and psychological morbidity. There is strong evidence that estrogen therapy may partly prevent this menopause-related change in body composition and the associated metabolic sequelae. However, further studies are required to identify the women most likely to gain metabolic benefit from menopausal hormone therapy in order to develop evidence-based clinical recommendations.
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/13697137.2012.707385
dc.identifier.eissn1473-0804
dc.identifier.issn1369-7137
dc.identifier.pubmedidMEDLINE:22978257
dc.identifier.urihttps://doi.org/10.3109/13697137.2012.707385
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77692
dc.identifier.wosidWOS:000308942500003
dc.information.autorucMedicina;Villaseca P;S/I;50271
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final429
dc.pagina.inicio419
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaCLIMACTERIC
dc.rightsacceso restringido
dc.subjectMENOPAUSE
dc.subjectOBESITY
dc.subjectWEIGHT GAIN
dc.subjectESTROGEN
dc.subjectHORMONE-BINDING GLOBULIN
dc.subjectQUALITY-OF-LIFE
dc.subjectBODY-MASS INDEX
dc.subjectESTROGEN REPLACEMENT THERAPY
dc.subjectGROWTH-FACTOR-I
dc.subjectPOSTMENOPAUSAL WOMEN
dc.subjectMETABOLIC SYNDROME
dc.subjectMIDLIFE WOMEN
dc.subjectWAIST CIRCUMFERENCE
dc.subjectSEXUAL DYSFUNCTION
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleUnderstanding weight gain at menopause
dc.typeartículo
dc.volumen15
sipa.codpersvinculados50271
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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