Candida parapsilosis and candida guillermondii: Emerging pathogens in nail candidiasis

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dc.contributor.authorFich, Félix
dc.contributor.authorAbarzúa, Alvaro
dc.contributor.authorPérez, M.
dc.contributor.authorNauhm, Y.
dc.contributor.authorLeón, E.
dc.date.accessioned2020-01-14T01:29:01Z
dc.date.available2020-01-14T01:29:01Z
dc.date.issued2014
dc.description.abstractBackground: Onychomycosis of the fingernails and toenails is generally caused by dermatophytes and yeasts. Toenail mycoses involve mainly dermatophytes but when Candida is also involved, the strain most commonly isolated worldwide is C. albicans. Aims: To determine Candida strains prevailing in onychomycosis. Materials and Methods: A retrospective, observational and descriptive study of fungal cultures retrieved from the registry of the microbiology laboratory of the Pontificia Universidad Católica was performed. Specimens obtained from patients attending the healthcare network between December 2007 and December 2010 was analyzed. Statistical Analysis: A descriptive statistical analysis was performed. Results: Candida was retrieved from 467 of 8443 specimens (52% fingernails and 48% toenails). Cultures were negative in 5320 specimens (63.6%). Among Candida-positive cultures, parapsilosis was the most commonly isolated strain with 202 cases (43.3%). While isolates of Candida guillermondii were 113 (24.2%), those of Candida albicans were 110 (23.6%), those of spp. were 20 (4.3%) and there were 22 cases of other isolates (4.71%). Among the 467 patients with positive cultures for Candida, 136 (29,1%) were men and 331 (70,9%) were women. All patients were older than 18 years old. Clinical files were available for only 169 of the 467 patients with positive cultures for Candida. For those, age, gender, underlying illnesses and use of immunossupresive agents during the trial was reviewed. Conclusions: The present study shows that both C. parapsilosis as well as C. guillermondii appear as emerging pathogens that would be in fact taking the place of C. albicans as the most commonly isolated pathogen in patients with Candida onychomycosis. The relative percentage of C parapsilosis increases every year. Identification of Candida strains as etiological agents of nail candidiasis becomes relevant to the management both nail as well as systemic candidiasis, in view of the resistance to conventional treatments readily reported in the literature.
dc.format.extent5 páginas
dc.identifier.doi10.4103/0019-5154.123485
dc.identifier.issn0019-5154
dc.identifier.urihttps://doi.org/10.4103/0019-5154.123485
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27466
dc.issue.numeroNo. 1
dc.pagina.final29
dc.pagina.inicio24
dc.revistaIndian Journal of Dermatologyes_ES
dc.rightsacceso abierto
dc.subjectCandidaes_ES
dc.subjectGuillermondies_ES
dc.subjectOnychomycosises_ES
dc.subjectParapsilosises_ES
dc.subjectArticlees_ES
dc.subjectCandida albicanses_ES
dc.subjectCandida famataes_ES
dc.subjectCandida glabrataes_ES
dc.subjectCandida guillermondiies_ES
dc.subjectCandida parapsilosises_ES
dc.subjectCandida tropicalises_ES
dc.subjectControlled studyes_ES
dc.subjectCultural anthropologyes_ES
dc.subjectDermatophytees_ES
dc.subjectDescriptive researches_ES
dc.subjectFemalees_ES
dc.subjectFingernail onychomycosises_ES
dc.subjectFungus culturees_ES
dc.subjectFungus isolationes_ES
dc.subjectHumanes_ES
dc.subjectImmunosuppressive treatmentes_ES
dc.subjectMajor clinical studyes_ES
dc.subjectMalees_ES
dc.subjectNail candidiasises_ES
dc.subjectNonhumanes_ES
dc.subjectObservational studyes_ES
dc.subjectRetrospective studyes_ES
dc.subjectToenail onychomycosises_ES
dc.subjectTrichophyton mentagrophyteses_ES
dc.subjectTrichophyton rubrumes_ES
dc.subjectTrichophyton tonsuranses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleCandida parapsilosis and candida guillermondii: Emerging pathogens in nail candidiasises_ES
dc.typeartículo
dc.volumenVol. 59
sipa.codpersvinculados1003970
sipa.codpersvinculados85465
sipa.codpersvinculados190246
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