Microbial hydroxylation of natural drimenic lactones
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Date
1999
Journal Title
Journal ISSN
Volume Title
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Abstract
Incubation of confertifolin and isodrimenin with Mucor plumbeus, Aspergillus niger or Rhizopus arrhizus gave in good yields the corresponding 3 beta-hydroxy derivatives. From isodrimenin, the known natural 7 alpha-hydroxy derivative (futronolide) was also obtained and its structure was definitely established by X-ray crystallographic study of its acetate derivative. (C) 1999 Elsevier Science Ltd. All rights reserved.
Description
Keywords
Mucor plumbeus, Aspergillus niger, Rhizopus arrhizus, biotransformation, hydroxylation, confertifolin, isodrimenin, TERPENIC SERIES, MUCOR-PLUMBEUS, DERIVATIVES, SESQUITERPENES, BIOCONVERSION, SCLAREOL, ROUTE