Spontaneous breathing promotes lung injury in an experimental model of alveolar collapse

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dc.catalogadorgrr
dc.contributor.authorBachmann Barrón, María Consuelo
dc.contributor.authorCruces, Pablo
dc.contributor.authorDíaz, Franco
dc.contributor.authorOrellana Oviedo, Vanessa Ivonne
dc.contributor.authorGoich, Mariela
dc.contributor.authorFuenzalida, José
dc.contributor.authorDamiani Rebolledo, L. Felipe
dc.contributor.authorBasoalto Escobar, Roque Ignacio
dc.contributor.authorJalil Contreras, Yorschua Frederick
dc.contributor.authorCarpio Cordero, David Bernardo
dc.contributor.authorHamidi Vadeghani, Majd Niki
dc.contributor.authorCornejo, Rodrigo
dc.contributor.authorRovegno Echavarria, David Maximiliano
dc.contributor.authorBugedo Tarraza, Guillermo
dc.contributor.authorBruhn Cruz, Alejandro
dc.contributor.authorRetamal Montes, Jaime
dc.date.accessioned2024-10-24T20:02:46Z
dc.date.available2024-10-24T20:02:46Z
dc.date.issued2022
dc.description.abstractVigorous spontaneous breathing has emerged as a promotor of lung damage in acute lung injury, an entity known as “patient self-inflicted lung injury”. Mechanical ventilation may prevent this second injury by decreasing intrathoracic pressure swings and improving regional air distribution. Therefore, we aimed to determine the effects of spontaneous breathing during the early stage of acute respiratory failure on lung injury and determine whether early and late controlled mechanical ventilation may avoid or revert these harmful effects. A model of partial surfactant depletion and lung collapse was induced in eighteen intubated pigs of 32 ±4 kg. Then, animals were randomized to (1) SB‐group: spontaneous breathing with very low levels of pressure support for the whole experiment (eight hours), (2) Early MV-group: controlled mechanical ventilation for eight hours, or (3) Late MV-group: first half of the experiment on spontaneous breathing (four hours) and the second half on controlled mechanical ventilation (four hours). Respiratory, hemodynamic, and electric impedance tomography data were collected. After the protocol, animals were euthanized, and lungs were extracted for histologic tissue analysis and cytokines quantification. SB-group presented larger esophageal pressure swings, progressive hypoxemia, lung injury, and more dorsal and inhomogeneous ventilation compared to the early MV-group. In the late MV-group switch to controlled mechanical ventilation improved the lung inhomogeneity and esophageal pressure swings but failed to prevent hypoxemia and lung injury. In a lung collapse model, spontaneous breathing is associated to large esophageal pressure swings and lung inhomogeneity, resulting in progressive hypoxemia and lung injury. Mechanical ventilation prevents these mechanisms of patient self-inflicted lung injury if applied early, before spontaneous breathing occurs, but not when applied late.
dc.fechaingreso.objetodigital2024-10-24
dc.format.extent13 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.1038/s41598-022-16446-2
dc.identifier.pubmedid35879511
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85134769329
dc.identifier.urihttps://doi.org/10.1038/s41598-022-16446-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88358
dc.identifier.wosidWOS:000830116000038
dc.information.autorucEscuela de Medicina; Bachmann Barrón, María Consuelo; 0000-0002-2006-0591; 215825
dc.information.autorucDepartamento de Ciencias de la Salud; Orellana Oviedo, Vanessa Ivonne; S/I; 1134356
dc.information.autorucDepartamento de Ciencias de la Salud; Damiani Rebolledo, L. Felipe; 0000-0002-8338-0488; 237645
dc.information.autorucEscuela de Medicina; Basoalto Escobar, Roque Ignacio; 0000-0002-8908-7397; 1010703
dc.information.autorucDepartamento de Ciencias de la Salud; Jalil Contreras, Yorschua Frederick; 0000-0002-4993-7158; 1079709
dc.information.autorucEscuela de Medicina; Carpio Cordero, David Bernardo; 0000-0002-9329-8285; 1015466
dc.information.autorucEscuela de Ingeniería; Hamidi Vadeghani, Majd Niki; S/I; 1045141
dc.information.autorucEscuela de Medicina; Rovegno Echavarria, David Maximiliano; 0000-0002-2882-8024; 1004053
dc.information.autorucEscuela de Medicina; Bugedo Tarraza, Guillermo ; 0000-0001-7527-6202; 60490
dc.information.autorucEscuela de Medicina; Bruhn Cruz, Alejandro ; 0000-0001-8034-1937; 741
dc.information.autorucEscuela de Medicina; Retamal Montes, Jaime ; 0000-0002-6817-3659; 175147
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final12661
dc.pagina.inicio12648
dc.revistaScientific Reports
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleSpontaneous breathing promotes lung injury in an experimental model of alveolar collapse
dc.typeartículo
dc.volumen12
sipa.codpersvinculados215825
sipa.codpersvinculados1134356
sipa.codpersvinculados237645
sipa.codpersvinculados1010703
sipa.codpersvinculados1079709
sipa.codpersvinculados1015466
sipa.codpersvinculados1045141
sipa.codpersvinculados1004053
sipa.codpersvinculados60490
sipa.codpersvinculados741
sipa.codpersvinculados175147
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