Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer

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dc.contributor.authorJackson, Sarah S.
dc.contributor.authorVan De Wyngard, Vanessa
dc.contributor.authorPfeiffer, Ruth M.
dc.contributor.authorCook, Paz
dc.contributor.authorHildesheim, Allan
dc.contributor.authorPinto, Ligia A.
dc.contributor.authorJackson, Sharon H.
dc.contributor.authorChoi, Kelvin
dc.contributor.authorVerdugo, Ricardo A.
dc.contributor.authorCuevas, Mara
dc.contributor.authorYanez, Cristian
dc.contributor.authorTobar-Calfucoy, Eduardo
dc.contributor.authorRetamales-Ortega, Rocio
dc.contributor.authorAraya, Juan Carlos
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorKoshiol, Jill
dc.date.accessioned2025-01-20T23:51:37Z
dc.date.available2025-01-20T23:51:37Z
dc.date.issued2021
dc.description.abstractChile has high incidence rates of gallbladder cancer globally, particularly among Amerindian women, who also have a high prevalence of gallstones. We examined differences in inflammatory biomarkers between Mapuche and non-Mapuche women from the Chile Biliary Longitudinal Study, a cohort of women with ultrasound-detected gallstones. We randomly selected 200 Mapuche women frequency matched to non-Mapuche women on age and statin use Inflammatory biomarkers were analyzed using a multiplex assay and linear regression to assess associations of a priori markers (CCL20, CXCL10, IL-6, and IL-8) with ethnicity. Novel biomarkers were analyzed using exploratory factor analysis (EFA) and sufficient dimension reduction (SDR) to identify correlated marker groups, followed by linear regression to examine their association with ethnicity. The mean values of IL-8 were higher in Mapuche than non-Mapuche women (P=0.04), while CCL20, CXCL10, and IL-6 did not differ significantly by ethnicity. EFA revealed two marker groups associated with ethnicity (P=0.03 and P<0.001). SDR analysis confirmed correlation between the biomarkers and ethnicity. We found higher IL-8 levels among Mapuche than non-Mapuche women. Novel inflammatory biomarkers were correlated with ethnicity and should be studied further for their role in gallbladder disease. These findings may elucidate underlying ethnic disparities in gallstones and carcinogenesis among Amerindians.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-021-83300-2
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-021-83300-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94828
dc.identifier.wosidWOS:000626726100059
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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