Overexpression of p73 as a Tissue Marker for High-Risk Gastritis

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dc.contributor.authorCarrasco, Gonzalo
dc.contributor.authorDiaz, Jose
dc.contributor.authorValbuena, Jose R.
dc.contributor.authorIbanez, Paulina
dc.contributor.authorRodriguez, Paz
dc.contributor.authorAraya, Gabriela
dc.contributor.authorRodriguez, Carolina
dc.contributor.authorTorres, Javiera
dc.contributor.authorDuarte, Ignacio
dc.contributor.authorAravena, Edmundo
dc.contributor.authorMena, Fernando
dc.contributor.authorBarrientos, Carlos
dc.contributor.authorCorvalan, Alejandro H.
dc.date.accessioned2024-01-10T13:51:42Z
dc.date.available2024-01-10T13:51:42Z
dc.date.issued2010
dc.description.abstractPurpose: Histologic assessment of high-risk gastritis for the development of gastric cancer is not well defined. The identification of tissue markers together with the integration of histologic features will be required for this assessment.
dc.description.abstractExperimental Design: Matched tumor/nontumor adjacent mucosa ( NTAM) of 91 early gastric cancer and 148 chronic gastritis cases were evaluated for histologic characteristics ( atrophy, intestinal metaplasia, chronic inflammation, polymorphonuclear infiltration, and Helicobacter pylori) by the Sydney System. Atrophy risk assessment was also evaluated by the Operative Link on Gastritis Assessment ( OLGA) staging system. Eight tissue markers ( BRCA1, HSP90, STAT1, FHIT, EGFR, p73, p53, p16INK4a) and EBV were also evaluated by tissue microarray/immunohistochemistry/in situ hybridization platform. Data were analyzed by contingency tables ( 2 x 2) using Fisher's exact two-tailed test ( P < 0.001) and integrated by Significance Analysis of Microarrays ( SAM) and clustering analysis.
dc.description.abstractResults: Histologically, NTAM have severe intestinal metaplasia/chronic inflammation and severe atrophy assessed by Sydney and OLGA staging systems. H. pylori infection was similar in both groups, and EBV was found only in 5.5% of the tumor samples. Overexpression of p73 was higher in NTAM ( 50.5%) than in chronic gastritis ( 10.8%; P < 0.0001). Integration of histologic features and tissue markers showed that overexpression of p73, severe atrophy, and OLGA stage 4 were the most relevant features in NTAM. Clustering analysis correctly assigned NTAM and control cases ( P < 0.0001).
dc.description.abstractConclusions: Overexpression of p73 should be considered for the assessment of high-risk chronic gastritis. SAM allows the integration of histology and tissue markers for this assessment. Clin Cancer Res; 16( 12); 3253-9. (C)2010 AACR.
dc.description.funderFondo Nacional de Ciencia y Tecnologia (FONDECYT)
dc.fechaingreso.objetodigital2024-05-16
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1158/1078-0432.CCR-09-2491
dc.identifier.eissn1557-3265
dc.identifier.issn1078-0432
dc.identifier.pubmedidMEDLINE:20530692
dc.identifier.urihttps://doi.org/10.1158/1078-0432.CCR-09-2491
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79620
dc.identifier.wosidWOS:000278749400020
dc.information.autorucMedicina;Araya G;S/I;149902
dc.information.autorucMedicina;Carrasco G;S/I;14818
dc.information.autorucMedicina;Corvalán AH;S/I;63885
dc.information.autorucMedicina;Duarte I;S/I;98528
dc.information.autorucMedicina;Ibáñez P;S/I;167330
dc.information.autorucMedicina;Rodríguez C;S/I;149906
dc.information.autorucMedicina;Rodríguez P;S/I;149953
dc.information.autorucMedicina;Torres J;S/I;95391
dc.information.autorucMedicina;Valbuena JR;S/I;1004589
dc.issue.numero12
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final3259
dc.pagina.inicio3253
dc.publisherAMER ASSOC CANCER RESEARCH
dc.revistaCLINICAL CANCER RESEARCH
dc.rightsacceso restringido
dc.subjectHIERARCHICAL-CLUSTERING ANALYSIS
dc.subjectCLINICOPATHOLOGICAL SIGNIFICANCE
dc.subjectEXPRESSION PROFILES
dc.subjectPROTEIN EXPRESSION
dc.subjectSYSTEMS PATHOLOGY
dc.subjectCANCER
dc.subjectCARCINOMA
dc.subjectHYPERMETHYLATION
dc.subjectADENOCARCINOMA
dc.subjectDYSPLASIA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOverexpression of p73 as a Tissue Marker for High-Risk Gastritis
dc.typeartículo
dc.volumen16
sipa.codpersvinculados149902
sipa.codpersvinculados14818
sipa.codpersvinculados63885
sipa.codpersvinculados98528
sipa.codpersvinculados167330
sipa.codpersvinculados149906
sipa.codpersvinculados149953
sipa.codpersvinculados95391
sipa.codpersvinculados1004589
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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