Highly efficient free-breathing 3D whole-heart imaging in 3-min: single center study in adults with congenital heart disease

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dc.article.number100008
dc.catalogadorjlo
dc.contributor.authorFotaki, Anastasia
dc.contributor.authorPushparajah, Kuberan
dc.contributor.authorRush, Christopher
dc.contributor.authorMuñoz, Camila
dc.contributor.authorVelasco, Carlos
dc.contributor.authorNeji, Radhouene
dc.contributor.authorKunze, Karl P.
dc.contributor.authorBotnar, René Michael
dc.contributor.authorPrieto Vásquez, Claudia Del Carmen
dc.date.accessioned2024-08-20T14:44:35Z
dc.date.available2024-08-20T14:44:35Z
dc.date.issued2024
dc.description.abstractBackground: Three dimensional, whole-heart (3DWH) MRI is an established non-invasive imaging modality in patients with congenital heart disease (CHD) for the diagnosis of cardiovascular morphology and for clinical decision making. Current techniques utilise diaphragmatic navigation (dNAV) for respiratory motion correction and gating and are frequently limited by long acquisition times. This study proposes and evaluates the diagnostic performance of a respiratory gating-free framework, which considers respiratory image-based navigation (iNAV), and highly accelerated variable density Cartesian sampling in concert with non-rigid motion correction and low-rank patch-based denoising (iNAV-3DWH-PROST). The method is compared to the clinical dNAV-3DWH sequence in adult patients with CHD. Methods: In this prospective single center study, adult patients with CHD who underwent the clinical dNAV-3DWH MRI were also scanned with the iNAV-3DWH-PROST. Diagnostic confidence (4-point Likert scale) and diagnostic accuracy for common cardiovascular lesions was assessed by three readers. Scan times and diagnostic confidence were compared using the Wilcoxon-signed rank test. Co-axial vascular dimensions at three anatomic landmarks were measured, and agreement between the research and the corresponding clinical sequence was assessed with Bland-Altman analysis. Results: The study included 60 participants (mean age ± [SD]: 33 ± 14 years; 36 men). The mean acquisition time of iNAV-3DWH-PROST was significantly lower compared with the conventional clinical sequence (3.1 ± 0.9 min vs 13.9 ± 3.9 min, p < 0.0001). Diagnostic confidence was higher for the iNAV-3DWH-PROST sequence compared with the clinical sequence (3.9 ± 0.2 vs 3.4 ± 0.8, p < 0.001), however there was no significant difference in diagnostic accuracy. Narrow limits of agreement and mean bias less than 0.08 cm were found between the research and the clinical vascular measurements. Conclusions: The iNAV-3DWH-PROST framework provides efficient, high quality and robust 3D whole-heart imaging in significantly shorter scan time compared to the standard clinical sequence.
dc.description.funderBiomedical Research Centre
dc.description.funderEPSRC
dc.description.funderNational Institute for Health Research
dc.description.funderFondecyt
dc.description.funderBHF Centre of Research Excellence
dc.description.funderWellcome EPSRC Centre for Medical Engineering
dc.format.extent10 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.jocmr.2023.100008
dc.identifier.eissn1532-429X
dc.identifier.issn1097-6647
dc.identifier.scopusidSCOPUS_ID:85182445660
dc.identifier.urihttp://doi.org/10.1016/j.jocmr.2023.100008
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87531
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Botnar, René Michael; 0000-0003-2811-2509; 1015313
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia Del Carmen; 0000-0003-4602-2523; 14195
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaJournal of Cardiovascular Magnetic Resonance
dc.rightsacceso restringido
dc.subject3D whole-heart
dc.subjectCongenital heart disease
dc.subjectINAV
dc.subjectLow-rank
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHighly efficient free-breathing 3D whole-heart imaging in 3-min: single center study in adults with congenital heart disease
dc.typeartículo
dc.volumen26
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
sipa.trazabilidadSCOPUS;2024-02-04
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