Mitochondrial Dynamics: a Potential New Therapeutic Target for Heart Failure

Simple item page
dc.contributor.authorKuzmicic, Jovan
dc.contributor.authordel Campo, Andrea
dc.contributor.authorLopez Crisosto, Camila
dc.contributor.authorMorales, Pablo E.
dc.contributor.authorPennanen, Christian
dc.contributor.authorBravo Sagua, Roberto
dc.contributor.authorHechenleitner, Jonathan
dc.contributor.authorZepeda, Ramiro
dc.contributor.authorCastro, Pablo F.
dc.contributor.authorVerdejo, Hugo E.
dc.contributor.authorParra, Valentina
dc.contributor.authorChiong, Mario
dc.contributor.authorLavandero, Sergio
dc.date.accessioned2024-01-10T14:23:31Z
dc.date.available2024-01-10T14:23:31Z
dc.date.issued2011
dc.description.abstractMitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. These events allow the transmission of signaling messengers and exchange of metabolites within the cell. They have also been implicated in a variety of biological processes including embryonic development, metabolism, apoptosis, and autophagy. Although the majority of these studies have been confined to noncardiac cells, emerging evidence suggests that changes in mitochondrial morphology could participate in cardiac development, the response to ischemia-reperfusion injury, heart failure, and diabetes mellitus. In this article, we review how the mitochondrial dynamics are altered in different cardiac pathologies, with special emphasis on heart failure, and how this knowledge may provide new therapeutic targets for treating cardiovascular diseases. Full English text available from: www.revespcardiol.org (C) 2011 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, SI. All rights reserved.
dc.fechaingreso.objetodigital09-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.recesp.2011.05.018
dc.identifier.eissn1579-2242
dc.identifier.issn0300-8932
dc.identifier.pubmedidMEDLINE:21820793
dc.identifier.urihttps://doi.org/10.1016/j.recesp.2011.05.018
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80107
dc.identifier.wosidWOS:000295809100012
dc.information.autorucFacultad de Medicina; Verdejo Pinochet, Hugo Eduardo; S/I; 1001175
dc.issue.numero10
dc.language.isoes
dc.nota.accesoContenido parcial
dc.pagina.final923
dc.pagina.inicio916
dc.publisherEDICIONES DOYMA S A
dc.rightsacceso restringido
dc.subjectCardiac metabolism
dc.subjectMitochondria
dc.subjectMitochondrial dynamics
dc.subjectHeart failure
dc.subjectMETABOLIC THERAPY
dc.subjectCREATINE-KINASE
dc.subjectFAILING HEART
dc.subjectRAT HEARTS
dc.subjectFUSION
dc.subjectAPOPTOSIS
dc.subjectCARDIOMYOPATHY
dc.subjectAUTOPHAGY
dc.subjectFISSION
dc.subjectOPA1
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMitochondrial Dynamics: a Potential New Therapeutic Target for Heart Failure
dc.typeartículo de revisión
dc.volumen64
sipa.codpersvinculados1001175
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-04-09. Mitochondrial Dynamics - a Potential New Therapeutic Target for Heart Failure.pdf
Size:
2.71 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas