New Cannabinoid receptor type 1 and 2 agonists and applications to understanding the endocannabinoid system: A chemical approach

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dc.catalogadorgjm
dc.contributor.authorFaúndez Parraguez, Manuel Ignacio
dc.date.accessioned2023-08-10T14:57:10Z
dc.date.available2023-08-10T14:57:10Z
dc.date.issued2023
dc.date.updated2023-08-09T20:04:14Z
dc.description.abstractThe modulation of the endocannabinoid system by synthetic ligands has allowed mediating several pathophysiological processes in the control of various diseases. The work of many chemists in designing drugs that activate cannabinoid receptors type I (CB1R) and type II (CB2R) has allowed exploring the structural requirements of new ligands to improve affinity and selectivity at both receptors. However, the functionality of these receptors remains poorly understood, and the efforts of medicinal chemists over the last 20 years have allowed the study and creation of new molecular templates to diversify the construction of new CB1R and CB2R agonists with potential therapeutic action. From the classical agonists derived from tetrahydrocannabinol and the agonist WIN-55,212-2, new compounds that modulate the signaling pathway of these receptors have been developed, and this review focuses on an analysis of various cannabinoid receptor agonists. A chemical description of the structural requirements that allowed new molecules with higher affinity and selectivity for these systems is provided.
dc.fechaingreso.objetodigital2023-08-10
dc.fuente.origenSIPA
dc.identifier.isbn978-0323908771
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/B9780323908771000061
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74381
dc.information.autorucEscuela de Química; Faúndez Parraguez, Manuel Ignacio; 0000-0002-1621-5327; 1058412
dc.language.isoen
dc.lugar.publicacionLondon, United Kingdom
dc.nota.accesoContenido parcial
dc.pagina.final416
dc.pagina.inicio397
dc.publisherAcademic Press
dc.relation.ispartofNeurobiology and Physiology of the Endocannabinoid System, Londres : Academic Press, 2023.
dc.rightsacceso restringido
dc.subjectCannabinoid agonists
dc.subjectIndoles
dc.subjectBenzimidazoles
dc.subjectPyridones
dc.subjectSynthesis
dc.subjectAffinity
dc.subjectSelectivity
dc.subjectDesign drugs
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNew Cannabinoid receptor type 1 and 2 agonists and applications to understanding the endocannabinoid system: A chemical approach
dc.typecapítulo de libro
sipa.codpersvinculados1058412
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