Mitochondrial function in spinal cord injury and regeneration

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dc.contributor.authorSlater, Paula G.
dc.contributor.authorDominguez-Romero, Miguel E.
dc.contributor.authorVillarreal, Maximiliano
dc.contributor.authorEisner, Veronica
dc.contributor.authorLarrain, Juan
dc.date.accessioned2024-01-10T14:25:50Z
dc.date.available2024-01-10T14:25:50Z
dc.date.issued2022
dc.description.abstractMany people around the world suffer from some form of paralysis caused by spinal cord injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of the central nervous system (CNS), which in mammals is unable to regenerate, and to date, there is a lack of full functional recovery therapies for SCI. These injuries start with a rapid and mechanical insult, followed by a secondary phase leading progressively to greater damage. This secondary phase can be potentially modifiable through targeted therapies. The growing literature, derived from mammalian and regenerative model studies, supports a leading role for mitochondria in every cellular response after SCI: mitochondrial dysfunction is the common event of different triggers leading to cell death, cellular metabolism regulates the immune response, mitochondrial number and localization correlate with axon regenerative capacity, while mitochondrial abundance and substrate utilization regulate neural stem progenitor cells self-renewal and differentiation. Herein, we present a comprehensive review of the cellular responses during the secondary phase of SCI, the mitochondrial contribution to each of them, as well as evidence of mitochondrial involvement in spinal cord regeneration, suggesting that a more in-depth study of mitochondrial function and regulation is needed to identify potential targets for SCI therapeutic intervention.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-03-19
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00018-022-04261-x
dc.identifier.eissn1420-9071
dc.identifier.issn1420-682X
dc.identifier.urihttps://doi.org/10.1007/s00018-022-04261-x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80378
dc.identifier.wosidWOS:000782439600002
dc.information.autorucFacultad de Ciencias Biológicas; Eisner Sagues, Veronica Raquel; S/I; 238175
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherSPRINGER BASEL AG
dc.rightsacceso restringido
dc.subjectMitochondria
dc.subjectSpinal cord
dc.subjectCell metabolism
dc.subjectCell death
dc.subjectImmune response
dc.subjectAxon regeneration
dc.subjectNeurogenesis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMitochondrial function in spinal cord injury and regeneration
dc.typereseña
dc.volumen79
sipa.codpersvinculados238175
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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