Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche

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dc.catalogadorjlo
dc.contributor.authorPonce, Diana
dc.contributor.authorRodríguez, Fernando
dc.contributor.authorMiranda, José P.
dc.contributor.authorBinder, Alexandra M.
dc.contributor.authorSantos, José L.
dc.contributor.authorMichels, Karin B.
dc.contributor.authorCutler, Gordon B.
dc.contributor.authorPereira, Ana
dc.contributor.authorIñiguez, Germán
dc.contributor.authorMericq, Verónica
dc.date.accessioned2024-01-19T15:29:25Z
dc.date.available2024-01-19T15:29:25Z
dc.date.issued2023
dc.description.abstractBiochemical premature adrenarche is defined by elevated serum DHEAS [≥40 μg/dL] before age 8 y in girls. This condition is receiving more attention due to its association with obesity, hyper-insulinemia, dyslipidemia, and polycystic ovary syndrome. Nevertheless, the link between early androgen excess and these risk factors remains unknown. Epigenetic modifications, and specifi-cally DNA methylation, have been associated with the initiation and progression of numerous disorders, including obesity and insulin resistance. The aim of this study was to determine if prepubertal androgen exposure is associated with a different methylation profile in pubertal girls. Eighty-six healthy girls were studied. At age 7 y, anthropometric measurements were begun and DHEAS levels were determined. Girls were classified into Low DHEAS (LD) [<42 μg/dL] and High DHEAS (HD) [≥42 μg/dL] groups. At Tanner stages 2 and 4 a DNA methylation microarray was performed to identify differentially methylated CpG positions (DMPs) between HD and LD groups. We observed a differential methylation pattern between pubertal girls with and without bio-chemical PA. Moreover, a set of DNA methylation markers, selected by the LASSO method, successfully distinguished between HD and LD girls regardless of Tanner stage. Additionally, a subset of these markers were significantly associated with glucose-related measures such as insulin level, HOMA-IR, and glycaemia. This pilot study provides evidence consistent with the hypothesis that high DHEAS concentration, or its hormonally active metabolites, may induce a unique blood methylation signature in pubertal girls, and that this methylation pattern is associated with altered glucose metabolism.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1080/15592294.2023.2200366
dc.identifier.issn1559-2294
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-85152600485&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80754
dc.information.autorucEscuela de Medicina; Miranda Marín, José Patricio; S/I; 1126717
dc.information.autorucEscuela de Medicina; Santos Martín José Luis; 0000-0003-2895-0369; 1005923
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final12
dc.pagina.inicio1
dc.revistaEpigenetics
dc.rightsacceso abierto
dc.subjectPremature adrenarche
dc.subjectDHEAS
dc.subjectMethylation
dc.subjectGlucose metabolism
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleDifferential methylation pattern in pubertal girls associated with biochemical premature adrenarche
dc.typeartículo
dc.volumen18
sipa.codpersvinculados1126717
sipa.codpersvinculados1005923
sipa.trazabilidadORCID;2024-01-08
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