Epstein-Barr virus-associated primary lymphoepitheliomalike carcinoma of the esophagus

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dc.contributor.authorValbuena, Jose Rafael
dc.contributor.authorRetamal, Yasmina
dc.contributor.authorBernal, Carolina
dc.contributor.authorEizuru, Yoshito
dc.contributor.authorCorvalan, Alejandro
dc.date.accessioned2024-01-10T12:05:15Z
dc.date.available2024-01-10T12:05:15Z
dc.date.issued2007
dc.description.abstractPrimary lymphoepitheliomalike carcinomas (LELC) of the esophagus are uncommon, with only 29 previously reported cases in the literature. Primary LELC of the esophagus is associated with Epstein-Barr virus (EBV). We herein report a 52-year-old man who presented with dysphagia and weight loss and was found to have a polypoid mass in the middle esophagus. Pathologic examination showed LELC. EBV infection was demonstrated by immunohistochemical detection of EBNA-1 in neoplastic cells and polymerase chain reaction amplification for EBNA-3C, BamHI-F, and W1/I1 regions but not by in situ hybridization by EBER-1 transcripts. EBV genotyping analysis demonstrated infection by a novel type "i"/XhoI loss recombinant strain. Although it is accepted that polymorphisms at BamHI-W1/I1 region cosegregate with polymorphisms at XhoI restriction site, this novel recombinant EBV has been identified in healthy donors and in nasal NK/T-cell lymphoma. To our knowledge, this is the first report that describes this recombinant type "i"/XhoI loss EBV strain in a primary LELC of the esophagus.
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/01.pdm.0000213473.77678.b7
dc.identifier.issn1052-9551
dc.identifier.pubmedidMEDLINE:17471155
dc.identifier.urihttps://doi.org/10.1097/01.pdm.0000213473.77678.b7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75975
dc.identifier.wosidWOS:000244733200004
dc.information.autorucMedicina;Corvalán A;S/I;63885
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final31
dc.pagina.inicio27
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaDIAGNOSTIC MOLECULAR PATHOLOGY
dc.rightsacceso restringido
dc.subjectEBV
dc.subjectlymphoepitheliomalike carcinoma
dc.subjectesophagus
dc.subjectCHINESE
dc.subjectSTRAIN
dc.subjectEBV
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEpstein-Barr virus-associated primary lymphoepitheliomalike carcinoma of the esophagus
dc.typeartículo
dc.volumen16
sipa.codpersvinculados63885
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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