Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice

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dc.contributor.authorAmigo, Ludwig
dc.contributor.authorHusche, Constanze
dc.contributor.authorZanlungo, Silvana
dc.contributor.authorLuetjohann, Dieter
dc.contributor.authorArrese, Marco
dc.contributor.authorMiquel, Juan F.
dc.contributor.authorRigotti, Attilio
dc.contributor.authorNervi, Flavio
dc.date.accessioned2024-01-10T13:11:41Z
dc.date.available2024-01-10T13:11:41Z
dc.date.issued2011
dc.description.abstractBackground & aims: Bile acid (BA) pool size remains unchanged after cholecystectomy (XGB) but it circulates faster, exposing the enterohepatic system to an increased flux of BA. Triglyceride (TG) and BA metabolisms are functionally inter-related. We investigated whether ablation of the gallbladder (GB) modifies hepatic TG metabolism. Methods: Male mice were subjected to XGB and fed a normal diet. In some experiments, mice received a 1% nicotinic acid diet to block lipolysis. Parameters of BA and TG metabolism, and microsomal triglyceride transfer protein (MTTP) activity were measured 1-2 months after XGB. Serum parameters, hepatic lipids and mRNA expression of genes of lipid metabolism were determined. Results: BA pool size and synthesis were normal, but biliary BA secretion doubled during the diurnal light phase in XGB mice. Serum and hepatic TG concentrations increased 25% (P < 0.02), and hepatic very-low-density lipoproteins (VLDL)-TG and apoB-48 productions increased 15% (P < 0.03) and 50% (P < 0.01), respectively, after XGB. Feeding a 1% nicotinic acid did normalize VLDL production. MTTP activity increased 15% (P < 0.005) after XGB. Hepatic free fatty acid (FFA) synthesis and content, and mRNA levels of lipid metabolism-related genes remained normal in XGD mice. Conclusions: XGB increased serum and hepatic TG levels, and VLDL production, which were restored to normal by nicotinic acid. The results suggest that FFA flux from adipose tissue to the liver is increased in XGB mice. They support the hypothesis that the GB has a role in the regulation of hepatic TG metabolism and that XGB may favour the accumulation of fat in the liver.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1478-3231.2010.02361.x
dc.identifier.eissn1478-3231
dc.identifier.issn1478-3223
dc.identifier.pubmedidMEDLINE:21040411
dc.identifier.urihttps://doi.org/10.1111/j.1478-3231.2010.02361.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78083
dc.identifier.wosidWOS:000285011000007
dc.information.autorucMedicina; Arrese M ;S/I;76095
dc.information.autorucMedicina;Amigo L;S/I;62028
dc.information.autorucMedicina;Miquel JF;S/I;72216
dc.information.autorucMedicina;Nervi F;S/I;99156
dc.information.autorucMedicina;Rigotti A;S/I;68489
dc.information.autorucMedicina;Zanlungo S;S/I;72650
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final64
dc.pagina.inicio52
dc.publisherWILEY
dc.revistaLIVER INTERNATIONAL
dc.rightsacceso restringido
dc.subjectcholecystectomy
dc.subjectgallbladder
dc.subjecthepatic fatty acid and triglyceride metabolism
dc.subjectVLDL production
dc.subjectBILIARY LIPID SECRETION
dc.subjectFIBROBLAST-GROWTH-FACTOR
dc.subjectBILE-ACIDS
dc.subjectMETABOLIC SYNDROME
dc.subjectTRANSFER PROTEIN
dc.subjectAPOLIPOPROTEIN-B
dc.subjectENTEROHEPATIC CIRCULATION
dc.subjectRAT HEPATOCYTES
dc.subjectTRANSGENIC MICE
dc.subjectFATTY LIVER
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice
dc.typeartículo
dc.volumen31
sipa.codpersvinculados76095
sipa.codpersvinculados62028
sipa.codpersvinculados72216
sipa.codpersvinculados99156
sipa.codpersvinculados68489
sipa.codpersvinculados72650
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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