ASSOCIATION BETWEEN PERINATAL FACTORS AND COMPONENTS OF THE METABOLIC SYNDROME AND INSULIN RESISTANCE IN CHILDREN OF PUENTE ALTO, SANTIAGO, CHILE

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dc.article.numberPO1025
dc.catalogadorpau
dc.contributor.authorMardones, Francisco
dc.contributor.authorPacheco, M.
dc.contributor.authorDominguez, Angélica
dc.contributor.authorVillarroel del Pino, Luis A.
dc.contributor.authorEriksson, J. G.
dc.contributor.authorArnáiz Gómez, Pilar
dc.contributor.authorBarja Y., Salesa
dc.contributor.authorCastillo Valenzuela, Oscar
dc.contributor.authorFarías Jofré, Marcelo
dc.date.accessioned2023-05-18T19:49:33Z
dc.date.available2023-05-18T19:49:33Z
dc.date.issued2013
dc.description.abstractBackground and objectives: we have previously studied the association of prenatal growth with metabolic syndrome (MS) components, including insulin resistance (IR), in about two thousand Chilean low-income urban school-age children (J Devel Orig Health Dis. 2012; 3(4): 237-244). We aim to ascertain with a higher sample size the influence of the above mentioned variables. Methods: retrospective cohort study linking information on MS and IR in school-age, with perinatal records. 3325 children were enrolled in schools in the district of Puente Alto (Santiago, Chile) during 2009-2011. Anthropometry and blood pressure (BP) were assessed. A blood sample for determination of glycemia, insulinemia (quimioluminiscence) and blood lipids was taken; HOMA was calculated and a national standard was applied to select HOMA-IR cases. Cook et al standard was used to define MS. We used Pearson correlation, chi-square test and logistic regression step-by-step. Linear and quadratic associations were tested with Poisson regression. Results: 3290 children had complete information at birth (98.9%) 52.01% women; aged 11.4 + 1 years. The prevalence of MS and IR was 7.26% and 25.47%, respectively. Logistic regression analysis showed an inverse association between birth length (BL), gestational age and birth weight (BW) with most dependent variables studied. However BW showed a direct association with the majority of the dependent variables studied. The waist circumference > 90th percentile, BP > 90th percentile and triglycerides > 110 mg/dl were associated with U-shaped BW, BL and ponderal index, respectively. Conclusions: In this new study we could demonstrate a higher number of U-shaped associations with perinatal variables. New studies with higher sample sizes would permit to show this kind of associations and improve our understanding of the early origins of metabolic diseases.
dc.format.extent1 página
dc.fuente.origenORCID
dc.identifier.doi10.1159/000354245
dc.identifier.issn0250-6807
dc.identifier.urihttps://doi.org/10.1159/000354245
dc.identifier.urihttps://publons.com/wos-op/publon/20543707
dc.identifier.urihttps://www.karger.com/Article/Abstract/354245
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67045
dc.information.autorucEscuela de Medicina ; Mardones, Francisco ; S/I ; 98805
dc.information.autorucPrograma de Estudios Generales College ; Dominguez, Angélica ; 0000-0001-7477-7574 ; 1239597
dc.information.autorucEscuela de Medicina ; Villarroel del Pino, Luis A. ; S/I ; 77182
dc.information.autorucEscuela de Medicina ; Arnáiz Gómez, Pilar ; S/I ; 98982
dc.information.autorucEscuela de Medicina ; Barja Y., Salesa ; 0000-0001-8583-188X ; 64532
dc.information.autorucEscuela de Medicina ; Castillo Valenzuela, Oscar ; S/I ; 1000391
dc.information.autorucEscuela de Medicina ; Farías Jofré, Marcelo ; 0000-0003-0473-2295 ; 12286
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final748
dc.pagina.inicio748
dc.revistaAnnals of Nutrition and Metabolism
dc.rightsacceso abierto
dc.subjectPrenatal growth
dc.subjectInsulin resistance
dc.subjectMetabolic syndrome
dc.subjectRetrospective cohort
dc.subjectChild
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleASSOCIATION BETWEEN PERINATAL FACTORS AND COMPONENTS OF THE METABOLIC SYNDROME AND INSULIN RESISTANCE IN CHILDREN OF PUENTE ALTO, SANTIAGO, CHILE
dc.typeartículo
dc.volumen63
sipa.codpersvinculados98805
sipa.codpersvinculados1239597
sipa.codpersvinculados77182
sipa.codpersvinculados98982
sipa.codpersvinculados64532
sipa.codpersvinculados1000391
sipa.codpersvinculados12286
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