Consenso de la Rama de Genética de la Sociedad Chilena de Pediatría sobre priorización de personas con Síndrome de Down y otras condiciones poco frecuentes en la Campaña de Vacunación COVID-19
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Date
2021
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Abstract
En el marco de la campaña de vacunación contra el virus SARS-CoV-2, el Ministerio de Salud de Chile solicitó asesoría a la de Rama de Genética de la Sociedad Chilena de Pediatría, para definir el nivel de priorización para pacientes con Síndrome de Down. Un panel de Genetistas trabajó en el desarrollo de este consenso, en el cual se incluyeron no solo los pacientes con Síndrome de Down, sino que se amplió la búsqueda a pacientes con otros tipos de discapacidades, en edades tanto pediátricas como adultas con el fin de aportar al desarrollo de medidas de salud pública frente a la pandemia de la COVID-19. El consenso concluye que, dados los antecedentes epidemiológicos de comorbilidades asociadas al Síndrome de Down, la mayor incidencia de casos de infección grave en este grupo de la población y mayor mortalidad, se debe considerar a los individuos con Trisomía 21 como una población de alto riesgo, y por ende, la vacunación contra SARS-CoV-2 debe tener prioridad alta para todas las personas con Síndrome de Down independiente de su edad (salvo el límite establecido por los ensayos clínicos de cada vacuna), debiendo ser precedidas solo por los grupos de personal de la salud y adultos con ≥ 60-65 años. Así mismo este grupo de expertos insta a las autoridades de salud a incluir como población prioritaria a las personas con discapacidad intelectual y condiciones relacionadas (otras anomalías cromosómicas diferentes a Síndrome de Down, discapacidad intelectual, anomalías congénitas y condiciones causantes de discapacidad con microcefalia), así como a los cuidadores de personas con este tipo de patologías. La vacunación en niños con este tipo de enfermedades debiera considerarse como parte del primer grupo de prioridad, una vez se disponga de vacunas contra SARS-CoV-2 seguras para ser empleadas en los niños, niñas y adolescentes.
In the framework of the vaccination campaign against the SARS-CoV-2 virus, the Chilean Ministry of Health requested advice from the Genetics Branch of the Chilean Society of Pediatrics, to define the level of prioritization for people with Down Syndrome . A panel of geneticists worked on the development of this consensus, in which not only patients with Down syndrome were included, but the search was extended to patients with other types of disabilities, in both pediatric and adult ages in or der to contribute to the development of public health measures against the COVID-19 pandemic. The consensus concludes that, given the prevalence of comorbidities associated with Down syndrome, the higher incidence of cases with severe COVID-19 in this population group and a higher mortality, individuals with trisomy 21 should be considered as a high-risk population, and therefore, vaccina tion against SARS-CoV-2 should have a high priority for all people with Down syndrome regardless of their age (except for the age limit established by the clinical trials of each vaccine), and should be preceded only by the groups of health personnel and adults aged > 60-65 years. Likewise, this group of experts urges health authorities to include people with intellectual disabilities and related conditions as a priority population (other chromosomal abnormalities other than Down syndrome, intellectual disability, congenital anomalies and conditions that cause disability with microcephaly), as well as the caregivers of people with this type of conditions. Vaccination in children with this type of disorders should be considered as part of the first priority group, once safe vaccines against SARS-CoV-2 are available for use in children and adolescents.
In the framework of the vaccination campaign against the SARS-CoV-2 virus, the Chilean Ministry of Health requested advice from the Genetics Branch of the Chilean Society of Pediatrics, to define the level of prioritization for people with Down Syndrome . A panel of geneticists worked on the development of this consensus, in which not only patients with Down syndrome were included, but the search was extended to patients with other types of disabilities, in both pediatric and adult ages in or der to contribute to the development of public health measures against the COVID-19 pandemic. The consensus concludes that, given the prevalence of comorbidities associated with Down syndrome, the higher incidence of cases with severe COVID-19 in this population group and a higher mortality, individuals with trisomy 21 should be considered as a high-risk population, and therefore, vaccina tion against SARS-CoV-2 should have a high priority for all people with Down syndrome regardless of their age (except for the age limit established by the clinical trials of each vaccine), and should be preceded only by the groups of health personnel and adults aged > 60-65 years. Likewise, this group of experts urges health authorities to include people with intellectual disabilities and related conditions as a priority population (other chromosomal abnormalities other than Down syndrome, intellectual disability, congenital anomalies and conditions that cause disability with microcephaly), as well as the caregivers of people with this type of conditions. Vaccination in children with this type of disorders should be considered as part of the first priority group, once safe vaccines against SARS-CoV-2 are available for use in children and adolescents.
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Keywords
Síndrome de Down, Inmunización, SARS-CoV-2, COVID-19, Discapacidad intelectual, Alteraciones Cromosómicas, Down Syndrome, Immunization, SARS-CoV-2, COVID-19, Intellectual disability, Chromosomal abnormalities