Plasminogen activator inhibitor type 1 serum levels and 4G/5G gene polymorphism in morbidly obese Hispanic patients with non-alcoholic fatty liver disease

Simple item page
dc.catalogadorgrr
dc.contributor.authorEspino Espino, Alberto Antonio
dc.contributor.authorVillagran Torres, Andrea Alejandra
dc.contributor.authorVollrath Reyes, Valeska Yolanda
dc.contributor.authorHanckes Mayo, Maria Paulina
dc.contributor.authorSalas Ocaranza, Roberto Ignacio
dc.contributor.authorFarah Samaan, Andrea Catherina
dc.contributor.authorSolis, Nancy
dc.contributor.authorPizarro Rojas, Margarita Alicia
dc.contributor.authorEscalona Perez, Alex Gamaliel
dc.contributor.authorBoza Wilson, Camilo
dc.contributor.authorPerez, Gustavo
dc.contributor.authorCarrasco, Gonzalo
dc.contributor.authorPadilla, Orlando
dc.contributor.authorFrancisco Miguel, Juan
dc.contributor.authorNervi Oddone, Flavio
dc.contributor.authorChavez Tapia, Norberto C.
dc.contributor.authorArab Verdugo, Juan Pablo
dc.contributor.authorAlvarez Lobos, Manuel Marcelo
dc.contributor.authorArrese Jimenez, Marco Antonio
dc.contributor.authorRiquelme Perez, Arnoldo Javier
dc.date.accessioned2024-08-06T21:53:19Z
dc.date.available2024-08-06T21:53:19Z
dc.date.issued2011
dc.description.abstractBackground. The plasminogen activator inhibitor type-1 (PAI-1) has been implicated in the regulation of fibrinolysis and extracellular matrix components. The single base pair guanine insertion/deletion polymorphism (4G/5G) within the promoter region of the PAI-1 gene influences PAI-1 synthesis and may modulate hepatic fibrogenesis. Aim. To evaluate the influence of PAI-1 serum levels and 4G/5G polymorphism on the risk of liver fibrosis associated to non-alcoholic fatty liver disease (NAFLD) in morbidly obese patients. Material and methods. Case-control study of 50 obese patients undergoing bariatric surgery and 71 non-obese subjects matched by age and sex. Anthropometric and biochemical measurements were performed, including PAI-1 serum levels. Genomic DNA was obtained to assess the presence of 4G/5G polymorphism. Results. BMI, insulinemia, triglycerides, HOMA-IR, hypertension and diabetes were significantly higher in obese patients compared to control subjects. PAI-1 serum levels observed in obese patients were significantly lower (10.63 +/- 4.82) compared to controls (14.26 +/- 11.4; p < 0.05). No differences were observed in the PAI-1 4G/5G promoter genotypes frequencies (p = 0.12). No differences were observed in PAI-1 plasma levels among obese patients with liver fibrosis (10.64 +/- 4.35) compared to patients without liver fibrosis (10.61 +/- 5.2; p = 0.985). PAI-1 4G/5G promoter genotypes frequencies were similar in patients with or without liver fibrosis associated to NASH (p = 0.6). Conclusions. Morbidly obese patients had significantly Lower PAI-1 serum levels with similar PAI-1 4G/5G genotypes frequencies compared to non-obese subjects. The frequency of 4G/5G genotypes in Chilean Hispanic healthy subjects was similar to that described in other populations. No association was found between PAI-1 serum levels or 4G/5G genotype with liver fibrosis in obese patients.
dc.description.funderFondo Nacional de Ciencia y Tecnologia de Chile (FONDECYT)
dc.fechaingreso.objetodigital2024-08-06
dc.format.extent9 pƔginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S1665-2681(19)31518-2
dc.identifier.issn1665-2681
dc.identifier.pubmedid21911891
dc.identifier.urihttps://doi.org/10.1016/S1665-2681(19)31518-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87305
dc.identifier.wosidWOS:000296672600012
dc.information.autorucEscuela de Medicina; Espino Espino, Alberto Antonio; 0000-0001-5707-6290; 146018
dc.information.autorucEscuela de Medicina; Villagran Torres, Andrea Alejandra; S/I; 1004414
dc.information.autorucEscuela de Medicina; Vollrath Reyes, Valeska Yolanda; S/I; 2185
dc.information.autorucEscuela de Medicina; Hanckes Mayo,Maria Paulina; S/I; 149931
dc.information.autorucEscuela de Medicina; Salas Ocaranza, Roberto Ignacio; S/I; 149947
dc.information.autorucEscuela de Medicina; Farah Samaan, Andrea Catherina; S/I; 134185
dc.information.autorucEscuela de Medicina; Pizarro Rojas, Margarita Alicia; 0000-0003-3063-3143; 102250
dc.information.autorucEscuela de Medicina; Escalona Perez, Alex Gamaliel; 0000-0001-5808-3679; 94025
dc.information.autorucEscuela de Medicina; Boza Wilson, Camilo; S/I; 761
dc.information.autorucEscuela de Medicina; Nervi Oddone, Flavio; 0000-0002-6642-7985; 99156
dc.information.autorucEscuela de Medicina; Arab Verdugo, Juan Pablo; 0000-0002-8561-396X; 132745
dc.information.autorucEscuela de Medicina; Alvarez Lobos, Manuel Marcelo; S/I; 6131
dc.information.autorucEscuela de Medicina; Arrese Jimenez, Marco Antonio; 0000-0002-0499-4191; 76095
dc.information.autorucEscuela de Medicina; Riquelme Perez, Arnoldo Javier; 0000-0002-8259-8960; 3538
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final501
dc.pagina.inicio493
dc.publisherElsevier EspaƱa
dc.revistaAnnals of Hepatology
dc.rightsacceso abierto
dc.rights.licenseCC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPlasminogen activator inhibitor type 1
dc.subjectSingle nucleotide polymorphisms
dc.subjectLiver fibrosis
dc.subjectNon-alcoholic fatty liver disease
dc.subjectSteatosis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePlasminogen activator inhibitor type 1 serum levels and 4G/5G gene polymorphism in morbidly obese Hispanic patients with non-alcoholic fatty liver disease
dc.typeartĆ­culo
dc.volumen10
sipa.codpersvinculados14818
sipa.codpersvinculados32517
sipa.codpersvinculados72216
sipa.codpersvinculados102063
sipa.codpersvinculados5510
sipa.codpersvinculados102379
sipa.codpersvinculados146018
sipa.codpersvinculados1004414
sipa.codpersvinculados2185
sipa.codpersvinculados149931
sipa.codpersvinculados149947
sipa.codpersvinculados134185
sipa.codpersvinculados102250
sipa.codpersvinculados94025
sipa.codpersvinculados761
sipa.codpersvinculados99156
sipa.codpersvinculados132745
sipa.codpersvinculados6131
sipa.codpersvinculados76095
sipa.codpersvinculados3538
sipa.trazabilidadWOS;05-06-2021
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S1665268119315182-main.pdf
Size:
203.52 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
ArtĆ­culos de revistas