Glycans in post-Golgi apical targeting: sorting signals or structural props?

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dc.contributor.authorRodriguez Boulan, E
dc.contributor.authorGonzalez, A
dc.date.accessioned2024-01-10T13:48:52Z
dc.date.available2024-01-10T13:48:52Z
dc.date.issued1999
dc.description.abstractA recent model proposed that N-glycans serve as apical targeting signals for soluble and membrane proteins in epithelial cells and neurons by interacting with lectin sorters in the trans-Golgi network. However, we believe that a number of experimental observations support an alternative hypothesis, that N-glycans play a facilitative role, by providing structural support or preventing aggregation of the proteins for example, thereby allowing interaction of proteinaceous apical sorting signals with the sorting machinery. This article discusses the experimental data currently available and how they relate to the proposed models.
dc.description.funderNATIONAL EYE INSTITUTE
dc.description.funderNATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
dc.description.funderNEI NIH HHS
dc.description.funderNIGMS NIH HHS
dc.fechaingreso.objetodigital2024-04-11
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0962-8924(99)01595-0
dc.identifier.eissn1879-3088
dc.identifier.issn0962-8924
dc.identifier.pubmedidMEDLINE:10407407
dc.identifier.urihttps://doi.org/10.1016/S0962-8924(99)01595-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79404
dc.identifier.wosidWOS:000081661800001
dc.information.autorucMedicina;González L;S/I;52306
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final294
dc.pagina.inicio291
dc.publisherELSEVIER SCIENCE LONDON
dc.revistaTRENDS IN CELL BIOLOGY
dc.rightsacceso restringido
dc.subjectPOLARIZED EPITHELIAL-CELLS
dc.subjectCANINE KIDNEY-CELLS
dc.subjectVESICULAR STOMATITIS-VIRUS
dc.subjectB SURFACE-ANTIGEN
dc.subjectMDCK CELLS
dc.subjectTRANSMEMBRANE DOMAIN
dc.subjectN-GLYCOSYLATION
dc.subjectMEMBRANE ANCHOR
dc.subjectSECRETION
dc.subjectPROTEIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGlycans in post-Golgi apical targeting: sorting signals or structural props?
dc.typeartículo
dc.volumen9
sipa.codpersvinculados52306
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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