High linoleic acid levels in red blood cells predict a poor response to neoadjuvant chemotherapy in human epidermal growth factor receptor type 2-positive breast cancer patients

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dc.catalogadorjlo
dc.contributor.authorRodrigo Valenzuela
dc.contributor.authorWalbaum García, Benjamín Vicente
dc.contributor.authorFarías Castro, Camila
dc.contributor.authorAcevedo Claros, Francisco Nicolás
dc.contributor.authorVargas Añazco, Catalina Andrea
dc.contributor.authorBennett Lason, José Tomás
dc.contributor.authorBravo, M. Loreto
dc.contributor.authorPinto, Mauricio P.
dc.contributor.authorMedina Araya, Lidia Marjorie
dc.contributor.authorMerino Lara, Tomás Rodrigo
dc.contributor.authorIbáñez Cáceres, Carolina
dc.contributor.authorParada Daza, Alejandra Cristina
dc.contributor.authorSánchez Rojel, César Giovanni
dc.date.accessioned2024-03-27T13:32:02Z
dc.date.available2024-03-27T13:32:02Z
dc.date.issued2024
dc.description.abstractObjective Polyunsaturated fatty acids are categorized as ω-3 or ⍵-6. Previous studies demonstrate that breast cancers display a high expression of fatty acid synthase and high fatty acid levels. Our study sought to determine if changes in plasma or red blood cell membrane fatty acid levels were associated with the response to preoperative (neoadjuvant) chemotherapy in non-metastatic breast cancer patients.MethodsOur prospective study assessed fatty acid levels in plasma and red blood cell membrane. Response to neoadjuvant chemotherapy was evaluated by the presence or absence of pathologic complete response and/or residual cancer burden.ResultsA total of 28 patients were included. First, patients who achieved pathologic complete response had significantly higher neutrophil-to-lymphocyte ratio versus no pathologic complete response (P = 0.003). Second, total red blood cell membrane polyunsaturated fatty acids were higher in the absence of pathologic complete response (P = 0.0028). Third, total red blood cell membrane ⍵-6 polyunsaturated fatty acids were also higher in no pathologic complete response (P < 0.01). Among ⍵-6 polyunsaturated fatty acids, red blood cell membrane linoleic acid was higher in the absence of pathologic complete response (P < 0.01). Notably, plasma polyunsaturated fatty acid, ⍵-6, and linoleic acid levels did not have significant differences. A multivariate analysis confirmed red blood cell membrane linoleic acid was associated with no pathologic complete response; this was further confirmed by receiver operating characteristic analysis (specificity = 92.3%, sensitivity = 76.9%, and area under the curve = 0.855).ConclusionsPending further validation, red blood cell membrane linoleic acid might serve as a predictor biomarker of poorer response to neoadjuvant chemotherapy in non-metastatic human epidermal growth factor receptor type 2–positive breast cancer. Measuring fatty acids in red blood cell membrane could offer a convenient, minimally invasive strategy to identifying patients more likely to respond or those with chemoresistance.
dc.format.extent7 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.nut.2024.112357
dc.identifier.issn0899-9007
dc.identifier.urihttp://dx.doi.org/10.1016/j.nut.2024.112357
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84751
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolas; 0000-0003-3482-7746; 119540
dc.information.autorucEscuela de Medicina; Walbaum García, Benjamín Vicente; 0000-0003-2314-5360; 163702
dc.information.autorucEscuela de Medicina; Vargas Añazco, Catalina Andrea; 0000-0001-8668-1457; 187239
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolás; 0000-0003-3482-7746; 119540
dc.information.autorucEscuela de Medicina; Bennett Lason, José Tomás; 0000-0001-6964-5841; 195686
dc.information.autorucEscuela de Enfermería; Medina Araya, Lidia Marjorie; S/I; 18566
dc.information.autorucEscuela de Medicina; Merino Lara, Tomás Rodrigo; 0000-0003-3661-9123; 119017
dc.information.autorucEscuela de Medicina; Ibáñez Cáceres, Carolina; S/I; 146063
dc.information.autorucDepartamento de Ciencias de la Salud; Parada Daza, Alejandra Cristina; S/I; 127953
dc.information.autorucEscuela de Medicina; Sánchez Rojel, César Giovanni; 0000-0002-2920-108X; 135644
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final7
dc.pagina.inicio1
dc.revistaNutrition
dc.rightsacceso restringido
dc.subjectBreast neoplasm
dc.subjectChemotherapy
dc.subjectBiomarkers
dc.subjectFatty acids
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleHigh linoleic acid levels in red blood cells predict a poor response to neoadjuvant chemotherapy in human epidermal growth factor receptor type 2-positive breast cancer patients
dc.typeartículo
dc.volumen121
sipa.codpersvinculados119540
sipa.codpersvinculados163702
sipa.codpersvinculados187239
sipa.codpersvinculados195686
sipa.codpersvinculados18566
sipa.codpersvinculados119017
sipa.codpersvinculados146063
sipa.codpersvinculados127953
sipa.codpersvinculados135644
sipa.trazabilidadORCID;2024-03-25
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