Cáncer de mama Her2-positivo: Terapias sistémicas actuales y experiencia local

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dc.catalogadorjlo
dc.contributor.authorWalbaum García, Benjamín Vicente
dc.contributor.authorAcevedo Claros, Francisco Nicolás
dc.contributor.authorCarrillo Barrientos, Diego Ignacio
dc.contributor.authorCamus Appuhn, Mauricio Gonzalo
dc.contributor.authorManzor V., Manuel
dc.contributor.authorMartinez R., Raúl
dc.contributor.authorVeglia Q., Paulina
dc.contributor.authorMurature S., Geraldine
dc.contributor.authorSalvado U., Valentina
dc.contributor.authorMuñiz Muñoz, María Sabrina
dc.contributor.authorMerino Lara, Tomás Rodrigo
dc.contributor.authorSanchez Rojel, César Giovanni
dc.date.accessioned2024-05-14T15:13:26Z
dc.date.available2024-05-14T15:13:26Z
dc.date.issued2023
dc.description.abstractBreast cancer (BC) is the leading cause of cancer death for women both worldwide and in Chile. Based on clinical, histological, and molecular features, studies have identified four BC subtypes that correlate with treatment sensitivity. Human Epidermal growth factor Receptor type 2-positive (HER2+) BC re-presents 15%-25% of newly diagnosed breast neoplasms; HER2+ BC is characterized by its aggressive behavior, early recurrence, and higher risk of brain metastasis. In recent years, HER2-targeted therapies have become the mainstay of treatment and have redefined the natural history of this subtype, reducing relapse rates for early-stage patients and increasing survival in advanced-stage patients. Herein we review novel treatment strategies and their mechanisms of action, along with clinical and real-world data. We also provide a summary of currently available treatments for this subtype and our local experience regarding the management of this disease.
dc.fechaingreso.objetodigital2024-09-02
dc.format.extent10 páginas
dc.identifier.doi10.35687/s2452-454920230011653
dc.identifier.eissn24524549
dc.identifier.issn2452-4557
dc.identifier.scopusidSCOPUS_ID:85147026946
dc.identifier.urihttps://doi.org/10.35687/s2452-454920230011653
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85591
dc.information.autorucEscuela de Medicina; Walbaum García, Benjamín Vicente; 0000-0003-2314-5360; 163702
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolás; 0000-0003-3482-7746; 119540
dc.information.autorucEscuela de Medicina; Carrillo Barrientos, Diego Ignacio; S/I; 205650
dc.information.autorucEscuela de Medicina; Camus Appuhn, Mauricio Gonzalo; 0000-0002-8409-5240; 100235
dc.information.autorucEscuela de Medicina; Muñiz Muñoz, María Sabrina; S/I; 1023831
dc.information.autorucEscuela de Medicina; Merino Lara, Tomás Rodrigo; 0000-0003-3661-9123; 119017
dc.information.autorucEscuela de Medicina; Sanchez Rojel, César Giovanni; 0000-0002-2920-108X; 135644
dc.issue.numero1
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final52
dc.pagina.inicio43
dc.revistaRevista de Cirugía
dc.rightsacceso abierto
dc.subjectBreast cancer
dc.subjectHER2
dc.subjectPertuzumab
dc.subjectTrastuzumab
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCáncer de mama Her2-positivo: Terapias sistémicas actuales y experiencia local
dc.title.alternativeHer2 positive breast cancer: Current systemic therapy and local experience
dc.typeartículo
dc.volumen75
sipa.codpersvinculados163702
sipa.codpersvinculados119540
sipa.codpersvinculados205650
sipa.codpersvinculados100235
sipa.codpersvinculados1023831
sipa.codpersvinculados119017
sipa.codpersvinculados135644
sipa.trazabilidadSCOPUS;02-03-2023
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