Imaging social and environmental factors as modulators of brain dysfunction: time to focus on developing, non-Western societies

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dc.catalogadorgrr
dc.contributor.authorCrossley Karmelic, Nicolas Andres
dc.contributor.authorAlliende Serra, Luz Maria
dc.contributor.authorOssandón Valdés, Tomás
dc.contributor.authorCastañeda, Carmen Paz
dc.contributor.authorGonzález-Valderrama, Alfonso
dc.contributor.authorUndurraga, Juan
dc.contributor.authorCastro, Mariana
dc.contributor.authorGuinjoan, Salvador
dc.contributor.authorDiaz-Zuluanga, Ana María
dc.contributor.authorPineda Zapata, Julian A.
dc.contributor.authorLopez-Jaramillo, Carlos
dc.contributor.authorReyes-Madrigal, Francisco
dc.contributor.authorDe la fuente Sandoval, Camilo
dc.contributor.authorLeón-Ortíz, Pablo
dc.contributor.authorSanguinetti Czepielewski, Leticia
dc.contributor.authorGama, Clarissa S.
dc.contributor.authorZugman, Andre
dc.contributor.authorGadelha, Ary
dc.contributor.authorJackowski, Andrea
dc.contributor.authorBressan, Rodrigo
dc.date.accessioned2024-06-04T17:59:48Z
dc.date.available2024-06-04T17:59:48Z
dc.date.issued2019
dc.description.abstractSocial and environmental factors are known risk factors and modulators of mental health disorders. We here conducted a nonsystematic review of the neuroimaging literature studying the effects of poverty, urbanicity, and community violence, highlighting the opportunities of studying non-Western developing societies such as those in Latin America. Social and environmental factors in these communities are widespread and have a large magnitude, as well as an unequal distribution, providing a good opportunity for their characterization. Studying the effect of poverty in these settings could help to explore the brain effect of economic improvements, disentangle the effect of absolute and relative poverty, and characterize the modulating impact of poverty on the underlying biology of mental health disorders. Exploring urbanicity effects in highly unequal cities could help identify the specific factors that modulate this effect as well as examine a possible dose-response effect by studying megacities. Studying brain changes in those living among violence, which is particularly high in places such as Latin America, could help to characterize the interplay between brain predisposition and exposure to violence. Furthermore, exploring the brain in an adverse environment should shed light on the mechanisms underlying resilience. We finally provide examples of two methodological approaches that could contribute to this field, namely a big cohort study in the developing world and a consortium-based meta-analytic approach, and argue about the potential translational value of this research on the development of effective social policies and successful personalized medicine in disadvantaged societies.
dc.description.funderConicyt/PBCT
dc.format.extent8 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.bpsc.2018.09.005
dc.identifier.issn0006-3223
dc.identifier.pubmedid30396768
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85055882108
dc.identifier.urihttps://doi.org/10.1016/j.bpsc.2018.09.005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86400
dc.identifier.wosidWOS:000494360200003
dc.information.autorucEscuela de Medicina; Crossley Karmelic, Nicolas Andres; 0000-0002-3060-656X; 11224
dc.information.autorucEscuela de Psicología; Alliende Serra, Luz Maria; 0000-0002-7648-9215; 196443
dc.information.autorucEscuela de Medicina; Ossandón Valdés, Tomás; 0000-0002-7306-7754; 1011810
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final15
dc.pagina.inicio8
dc.revistaBiological psychiatry. Cognitive neuroscience and neuroimaging
dc.rightsacceso restringido
dc.subjectDeveloping world
dc.subjectNeuroimaging
dc.subjectPoverty
dc.subjectUrbanicity
dc.subjectPsychiatric disorders
dc.subjectViolence
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods01 No poverty
dc.subject.odspa01 Fin de la pobreza
dc.titleImaging social and environmental factors as modulators of brain dysfunction: time to focus on developing, non-Western societies
dc.typeartículo de revisión
dc.volumen4
sipa.codpersvinculados11224
sipa.codpersvinculados196443
sipa.codpersvinculados1011810
sipa.trazabilidadHistorial Académico;09-07-2021
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