Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile.

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dc.contributor.authorHernández Vargas, Caroll Daffner
dc.contributor.authorCasanello Toledo, Paola Cecilia
dc.contributor.authorHarris D., Paul R.
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorIturriaga, Carolina
dc.contributor.authorPérez Mateluna, Guillermo
dc.contributor.authorFarías Jofré, Marcelo Enrique
dc.contributor.authorUrzúa, Marcela
dc.contributor.authorHernández Carreño, Cherie Francisca
dc.contributor.authorSerrano Honeyman, Carolina
dc.contributor.authorHernández Vargas, Caroll Daffner
dc.contributor.authorCasanello Toledo, Paola Cecilia
dc.contributor.authorHarris D., Paul R.
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorIturriaga, Carolina
dc.contributor.authorPérez Mateluna, Guillermo
dc.contributor.authorFarías Jofré, Marcelo Enrique
dc.contributor.authorUrzúa, Marcela
dc.contributor.authorHernández Carreño, Cherie Francisca
dc.contributor.authorSerrano Honeyman, Carolina
dc.date.accessioned2020-04-21T18:03:08Z
dc.date.available2020-04-21T18:03:08Z
dc.date.issued2020
dc.date.updated2020-04-19T00:03:19Z
dc.description.abstractAbstract Background Growing evidence shows that atopic dermatitis (AD), food allergy (FA), allergic rhinitis, and asthma are largely determined during the first 1000 days (time elapsed from conception to the 2nd birthday). The ARIES birth cohort aims to determine prenatal and perinatal conditions, as well as genetic and epigenetic factors, that participate in the early setting of immune responses, and the role of these in the later determination of the risk of allergic diseases and asthma in the offspring. Methods We have designed a birth cohort of 250 families with prenatal recruitment (~ 14 weeks). We will genotype relevant allergy/asthma-associated variants in trios and will perform immunophenotyping and evaluation of allergy biomarkers in cord blood. At 1 and 2 years of age we will assess if infants have developed allergic sensitization, AD, FA, as well as biomarkers of asthma including the asthma predictive index. We will also evaluate how maternal conditions modify immune programming through epigenetic modifications and will then depict newborn epigenetic cues of allergy/asthma risk. Next, we will assess composition/diversity of maternal gut, placenta, breastmilk and infant gut microbiome and their association with immunophenotype and biomarkers at birth, and clinical outcomes at age 1 and 2. Finally, we plan to assess how environmental exposures (perinatal outdoor and indoor pollution, allergens and endotoxin) affect the incidence of allergic sensitization, AD, FA, and risk of asthma. Discussion The in-depth study of the ARIES birth cohort shall provide crucial information to understand the rising incidence of allergies and asthma in developing countries, and hopefully provide cues on how to prevent and treat these diseases. Trial registration clinicaltrials.gov NCT04186949, retrospectively registered on December 5, 2019.
dc.identifier.citationBMC Pediatrics. 2020 Apr 15;20(1):164
dc.identifier.doi10.1186/s12887-020-02077-x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/28693
dc.issue.numeroNo. 164
dc.language.isoen
dc.pagina.final9
dc.pagina.inicio1
dc.revistaBMC Pediatricses_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectBirth cohortes_ES
dc.subjectCohort studyes_ES
dc.subjectAllergyes_ES
dc.subjectAsthmaes_ES
dc.subjectPrenatal conditionses_ES
dc.subjectFood allergyes_ES
dc.subjectAtopic dermatitises_ES
dc.subject.ddc616.97
dc.subject.deweyMedicina y saludes_ES
dc.titleEarly origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile.es_ES
dc.typeartículo
dc.volumenVol. 20
sipa.codpersvinculados149722
sipa.codpersvinculados146772
sipa.codpersvinculados80706
sipa.codpersvinculados113247
sipa.codpersvinculados12286
sipa.codpersvinculados15296
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