C-Reactive protein levels in patients with chronic obstructive pulmonary disease

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dc.contributor.authorDiaz, Orlando
dc.contributor.authorParada, Alejandra
dc.contributor.authorRamos, Cristobal
dc.contributor.authorKlaassen, Julieta
dc.contributor.authorCarlos Diaz, Juan
dc.contributor.authorAndresen, Max
dc.contributor.authorLisboa, Carmen
dc.contributor.authorSaldias, Fernando
dc.date.accessioned2024-01-10T13:47:13Z
dc.date.available2024-01-10T13:47:13Z
dc.date.issued2012
dc.description.abstractBackground: Patients with chronic obstructive pulmonary disease (COPD) have elevated serum levels of ultrasensitive C reactive protein (CRPus). This raise may be related directly to COPD and its associated systemic inflammation or secondary to other factors such as smoking status, disease severity, acute exacerbations, or associated complications. Aim: To evaluate the potential causes of raised levels of CRPus in stable COPD patients. Patients and Methods: Cohorts of 133 mild-to-very severe COPD patients (41 current smokers), 31 never-smokers, and 33 current smoker controls were compared. Clinical assessments included body mass index (BMA fat (FM) and fat-free mass (FFM) measurement by DEXA, forced expiratory volume in one second (FEV1), arterial oxygen tension (PaO2), six-minute walking test (SMWT), emphysema (EMPH) and right thigh muscle cross-sectional area (TMCSA), both quantified by high resolution computed tomography. Results: Serum CRPus levels were significantly higher in COPD patients than in controls (7 +/- 4.2 and 3.7 +/- 2.7 mg/L, respectively; p < 0.0001). Being smoker did not influence CRPus levels. These levels were significantly correlated with FM (r = 0.30), BMI (r = 0.21), FEV1 (r = -0.21), number of acute exacerbations of the disease in the last year (r = 0.28), and PaO2 (r = -0.27). Using multivariate analysis FM, PaO2, and number of acute exacerbations of the disease in the last year had the strongest association with CRPus levels. Conclusions: CRPus is elevated in COPD patients, independent of smoking status. It is weakly associated with fat mass, arterial oxygen tension and frequency of exacerbations. (Rev Med Chile 2012; 140: 569-578).
dc.fechaingreso.objetodigital2024-05-28
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872012000500003
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:23096661
dc.identifier.urihttps://doi.org/10.4067/S0034-98872012000500003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79248
dc.identifier.wosidWOS:000305354300003
dc.information.autorucMedicina;Andresen M ;S/I;54274
dc.information.autorucMedicina;Diaz O ;S/I;78564
dc.information.autorucMedicina;Klaassen J ;S/I;100024
dc.information.autorucMedicina;Lisboa C ;S/I;98551
dc.information.autorucMedicina;Saldias F;S/I;67197
dc.issue.numero5
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final578
dc.pagina.inicio569
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso abierto
dc.subjectEmphysema
dc.subjectC-reactive protein
dc.subjectPulmonary disease, chronic obstructive
dc.subjectSystemic inflammatory response syndrome
dc.subjectCORONARY-HEART-DISEASE
dc.subjectSYSTEMIC INFLAMMATION
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectCIGARETTE-SMOKING
dc.subjectBODY-COMPOSITION
dc.subjectREFERENCE VALUES
dc.subjectLUNG-FUNCTION
dc.subjectRISK-FACTORS
dc.subjectCOPD
dc.subjectMARKERS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleC-Reactive protein levels in patients with chronic obstructive pulmonary disease
dc.typeartículo
dc.volumen140
sipa.codpersvinculados54274
sipa.codpersvinculados78564
sipa.codpersvinculados100024
sipa.codpersvinculados98551
sipa.codpersvinculados67197
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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