Customized normothermic machine perfusion decreases ischemia–reperfusion injury compared with static cold storage in a porcine model of liver transplantation

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dc.catalogadorgjm
dc.contributor.authorRiveros González, Sergio
dc.contributor.authorMarino C., Carlo
dc.contributor.authorOchoa Suazo, Gabriela Susana
dc.contributor.authorSoto Muñoz, Dagoberto Igor
dc.contributor.authorAlegría Vargas, Leyla
dc.contributor.authorZenteno, María José
dc.contributor.authorSan Martín, Sebastián
dc.contributor.authorBrañes, Alejandro
dc.contributor.authorAchurra Tirado, Pablo
dc.contributor.authorRebolledo Acevedo, Rolando
dc.date.accessioned2024-03-13T20:14:23Z
dc.date.available2024-03-13T20:14:23Z
dc.date.issued2023
dc.description.abstractBackground: Liver transplantation has been demonstrated to be the best treatment for several liver diseases, while grafts are limited. This has caused an increase in waiting lists, making it necessary to find ways to expand the number of organs available for transplantation. Normothermic perfusion (NMP) of liver grafts has been established as an alternative to static cold storage (SCS), but only a small number of perfusion machines are commercially available. Methods: Using a customized ex situ machine perfusion, we compared the results between ex situ NMP and SCS preservation in a porcine liver transplant model. Results: During NMP, lactate concentrations were 80% lower after the 3-h perfusion period, compared with SCS. Bile production had a 2.5-fold increase during the NMP period. After transplantation, aspartate transaminase (AST) and alanine transaminase (ALT) levels were 35% less in the NMP group, compared to the SCS group. In pathologic analyses of grafts after transplant, tissue oxidation did not change between groups, but the ischemia–reperfusion injury score was lower in the NMP group. Conclusion: NMP reduced hepatocellular damage and ischemia–reperfusion injury when compared to SCS using a customized perfusion machine. This could be an alternative for low-income countries to include machine perfusion in their therapeutic options.
dc.fechaingreso.objetodigital2024-09-02
dc.fuente.origenORCID
dc.identifier.doi10.1111/aor.14390
dc.identifier.eissn1525-1594
dc.identifier.issn0160-564X
dc.identifier.urihttps://doi.org/10.1111/aor.14390
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84387
dc.information.autorucEscuela de Medicina; Riveros González, Sergio; S/I; 178359
dc.information.autorucEscuela de Medicina; Marino C., Carlo; S/I; 199753
dc.information.autorucEscuela de Medicina; Ochoa Suazo, Gabriela Susana; S/I; 1083346
dc.information.autorucEscuela de Medicina; Soto Muñoz, Dagoberto Igor; S/I; 1008458
dc.information.autorucEscuela de Medicina; Alegría Vargas, Leyla; 0000-0002-0930-4452; 121090
dc.information.autorucEscuela de Medicina; Achurra Tirado, Pablo; S/I; 156236
dc.information.autorucEscuela de Medicina; Rebolledo Acevedo, Rolando; 0000-0003-3501-4042; 127520
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final159
dc.pagina.inicio148
dc.revistaArtificial Organs
dc.rightsacceso restringido
dc.subjectGraft preservation
dc.subjectLiver viability
dc.subjectMachine perfusion
dc.subjectOrgan preservation
dc.subjectTransplantation
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCustomized normothermic machine perfusion decreases ischemia–reperfusion injury compared with static cold storage in a porcine model of liver transplantation
dc.typeartículo
dc.volumen47
sipa.codpersvinculados178359
sipa.codpersvinculados199753
sipa.codpersvinculados1083346
sipa.codpersvinculados1008458
sipa.codpersvinculados121090
sipa.codpersvinculados156236
sipa.codpersvinculados127520
sipa.trazabilidadORCID;2024-03-11
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