Gastric cancer is related to early Helicobacter pylori infection in a high-prevalence country

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dc.contributor.authorFerreccio, Catterina
dc.contributor.authorRollan, Antonio
dc.contributor.authorHarris, Paul R.
dc.contributor.authorSerrano, Carolina
dc.contributor.authorGederlini, Alessandra
dc.contributor.authorMargozzini, Paula
dc.contributor.authorGonzalez, Claudia
dc.contributor.authorAguilera, Ximena
dc.contributor.authorVenegas, Alejandro
dc.contributor.authorJara, Alejandro
dc.date.accessioned2024-01-10T12:39:11Z
dc.date.available2024-01-10T12:39:11Z
dc.date.issued2007
dc.description.abstractBackground and Aims: Chile ranks fifth in the world among countries with the highest incidence of gastric cancer. The aim was to quantify the association between Helicobacter pylori infection and gastric cancer mortality at the county of residence.
dc.description.abstractMethods: A cross-sectional household survey, a probability sample of the Chilean adult population, provided 2,615 participants in whom serum H. pylori IgG antibodies were measured (ELISA). The spatial pattern of 48,367 deaths due to gastric cancer which occurred from 1985 to 2002 was analyzed using a hierarchical Poisson regression model; 333 counties were categorized as low, medium, and high gastric cancer mortality with median gastric cancer death rates of 11.4, 19.1, and 26.0 per 100,000 inhabitants, respectively. The association between H. pylori positivity and gastric cancer mortality in the county of residence was assessed by multivariate Poisson regression for complex samples.
dc.description.abstractResults: H. pylori prevalence was 73.0% [95% confidence intervals (CI), 70.0-76.01, higher in men [prevalence rate ratio (PRIZ), 1.1 (95% Cl, 1.01-1.20)], peaked at ages 45 to 64, and dropped after age 65. It was higher among residents in counties with high gastric cancer mortality (79.7%; 95% Cl, 76.4-82.6) compared to counties with low gastric cancer mortality (62.3%; 95% Cl, 53.8-70.2; corresponding PRR, 1.3; 95% Cl, 1.1-1.5); under age 24, H. pylori infection was 79.7% (95% CI, 72.2-85.6) versus 39.8% (95% Cl, 19.6-64.2) among residents in counties with high and low gastric cancer mortalities, respectively (PRR, 2.0; 95% CI, 1.1-3.7).
dc.description.abstractConclusions: The high prevalence of H. pylori at younger ages was associated with high gastric cancer mortality in the base population.
dc.fechaingreso.objetodigital2024-05-16
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1158/1055-9965.EPI-06-0514
dc.identifier.eissn1538-7755
dc.identifier.issn1055-9965
dc.identifier.pubmedidMEDLINE:17416755
dc.identifier.urihttps://doi.org/10.1158/1055-9965.EPI-06-0514
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77157
dc.identifier.wosidWOS:000245732600005
dc.information.autorucMedicina;Ferreccio C;S/I;99684
dc.information.autorucMedicina;Harris P;S/I;80706
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final667
dc.pagina.inicio662
dc.publisherAMER ASSOC CANCER RESEARCH
dc.revistaCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
dc.rightsacceso restringido
dc.subjectRAPID UREASE TEST
dc.subjectTRANSMISSION
dc.subjectBIOPSIES
dc.subjectENIGMAS
dc.subjectNUMBER
dc.subjectCHILE
dc.subjectTESTS
dc.subjectSIZE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGastric cancer is related to early Helicobacter pylori infection in a high-prevalence country
dc.typeartículo
dc.volumen16
sipa.codpersvinculados99684
sipa.codpersvinculados80706
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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