Naturalization of the microbiota developmental trajectory of Cesarean-born neonates after vaginal seeding

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dc.catalogadorjwg
dc.contributor.authorSong, Se Jin
dc.contributor.authorWang, Jincheng
dc.contributor.authorMartino, Cameron
dc.contributor.authorJiang, Lingjing
dc.contributor.authorThompson, Wesley K.
dc.contributor.authorShenhav, Liat
dc.contributor.authorMcDonald, Daniel
dc.contributor.authorMarotz, Clarisse
dc.contributor.authorHarris Diez, Paul Richard
dc.contributor.authorHernandez, Caroll D.
dc.contributor.authorHenderson, Nora
dc.contributor.authorAckley, Elizabeth
dc.contributor.authorNardella, Deanna
dc.contributor.authorGillihan, Charles
dc.contributor.authorMontacuti, Valentina
dc.contributor.authorSchweizer, William
dc.contributor.authorJay, Melanie
dc.contributor.authorCombellick, Joan
dc.contributor.authorSun, Haipeng
dc.contributor.authorGarcia Mantrana, Izaskun
dc.contributor.authorRaga, Fernando Gil
dc.contributor.authorCollado, Maria Carmen
dc.contributor.authorRivera Vinas, Juana, I
dc.contributor.authorCampos Rivera, Maribel
dc.contributor.authorRuiz Calderon, Jean F.
dc.contributor.authorKnight, Rob
dc.contributor.authorDominguez Bello, Maria Gloria
dc.date.accessioned2024-01-11T19:43:43Z
dc.date.available2024-01-11T19:43:43Z
dc.date.issued2021
dc.description.abstractBackground: Early microbiota perturbations are associated with disorders that involve immunological underpinnings. Cesarean section (CS)-born babies show altered microbiota development in relation to babies born vaginally. Here we present the first statistically powered longitudinal study to determine the effect of restoring exposure to maternal vaginal fluids after CS birth.
dc.description.abstractMethods: Using 16S rRNA gene sequencing, we followed the microbial trajectories of multiple body sites in 177 babies over the first year of life; 98 were born vaginally, and 79 were born by CS, of whom 30 were swabbed with a maternal vaginal gauze right after birth.
dc.description.abstractFindings: Compositional tensor factorization analysis confirmed that microbiota trajectories of exposed CS-born babies aligned more closely with that of vaginally born babies. Interestingly, the majority of amplicon sequence variants from maternal vaginal microbiomes on the day of birth were shared with other maternal sites, in contrast to non-pregnant women from the Human Microbiome Project (HMP) study.
dc.description.abstractConclusions: The results of this observational study prompt urgent randomized clinical trials to test whether microbial restoration reduces the increased disease risk associated with CS birth and the underlying mechanisms. It also provides evidence of the pluripotential nature of maternal vaginal fluids to provide pioneer bacterial colonizers for the newborn body sites. This is the first study showing long-term naturalization of the microbiota of CS-born infants by restoring microbial exposure at birth.
dc.description.funderEmch Fund
dc.description.funderCIFAR
dc.description.funderNorwegian Institute of Public Health
dc.description.funderNational Institute of Justice
dc.description.funderJanssen
dc.description.funderC D
dc.description.funderChilean CONICYT
dc.description.funderSOCHIPE
dc.description.funderNIH
dc.description.funderEmerald Foundation
dc.fechaingreso.objetodigital2023-01-11
dc.format.extent20 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.medj.2021.05.003
dc.identifier.issn2666-6340
dc.identifier.urihttps://doi.org/10.1016/j.medj.2021.05.003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80433
dc.identifier.wosidWOS:000686159800010
dc.information.autorucEscuela de Medicina; Harris Diez Paul Richard; 0000-0001-6226-0957; 80706
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.inicio951
dc.publisherELSEVIER
dc.revistaMED
dc.rightsacceso abierto
dc.subjectGUT MICROBIOME
dc.subjectEARLY-LIFE
dc.subjectDELIVERY
dc.subjectSECTION
dc.subjectSHAPES
dc.subjectASSOCIATION
dc.subjectCHILDHOOD
dc.subjectCHILDREN
dc.subjectMODE
dc.subjectRISK
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNaturalization of the microbiota developmental trajectory of Cesarean-born neonates after vaginal seeding
dc.typeartículo
dc.volumen2
sipa.codpersvinculados80706
sipa.trazabilidadWOS;18-03-2022
sipa.trazabilidadORCID;2024-01-08
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