Biomarcadores coronarios y evolución clínica alejada en pacientes con síndromes coronarios agudos sin elevación del segmento ST

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dc.catalogadorpau
dc.contributor.authorBaeza Vergara, Ricardo Gabriel
dc.contributor.authorCorbalán Herreros, Ramón
dc.contributor.authorCastro Gálvez, Pablo Federico
dc.contributor.authorAcevedo B., Mónica
dc.contributor.authorQuiroga G., Teresa
dc.contributor.authorViviani García, Paola
dc.date.accessioned2023-05-18T19:49:40Z
dc.date.available2023-05-18T19:49:40Z
dc.date.issued2005
dc.description.abstractThe use of new biomarkers improved risk stratification for patients with acute coronary syndromes (ACS). Aim: To evaluate the relationship between multiple biomarkers and long-term clinical outcome in ACS without ST segment elevation. Patients and Methods: Consecutive patients presenting with suspected ACS were studied. On admission to the emergency room, serum was obtained to determine highly sensitive C reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), lipoprotein (a) (LPa) and soluble P selectin (sPS). Clinical endpoints were mortality and a composite endpoint of major adverse cardiovascular events (MACE) including death, re-infarction, and angina. Results: Seventy patients, aged 63±13 years, 54 males, were studied. Final diagnosis was unstable angina in 71% and non-ST-segment elevation myocardial infarction in 29%. MACE and mortality rate were 17% and 5.8%, respectively. We found higher plasma levels of hsCRP, ESR and Lp(a) in patients with MACE (p=0.032, p=0.015 and p=0.010, respectively). Plasma levels of hsCRP and ESR were also higher in patients who died during the follow up (p=0.002 y p=0.045, respectively). Conclusion: Plasma levels of inflammatory markers and atherosclerosis biomarkers are associated with a worse long-term clinical outcome in ACS without ST segment elevation. The inclusion of these biomarkers in the routine blood test on admission, could improve risk stratification of patients with ACS in the future (Rev Méd Chile 2005; 133: 1275-93).
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.doi10.4067/S0034-98872005001100003
dc.identifier.issn0034-9887
dc.identifier.urihttp://dx.doi.org/10.4067/S0034-98872005001100003
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-31144446915&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67083
dc.information.autorucEscuela de Medicina ; Baeza Vergara, Ricardo Gabriel ; S/I ; 85018
dc.information.autorucEscuela de Medicina ; Corbalán Herreros, Ramón ; 0000-0002-4675-6191 ; 98700
dc.information.autorucEscuela de Medicina ; Castro Gálvez, Pablo Federico ; 0000-0002-9320-1703 ; 100212
dc.information.autorucEscuela de Medicina ; Acevedo B., Mónica ; S/I ; 81173
dc.information.autorucEscuela de Medicina ; Viviani García, Paola ; S/I ; 729
dc.issue.numero11
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final1293
dc.pagina.inicio1285
dc.revistaRevista Médica de Chile
dc.rightsacceso abierto
dc.subjectAngina, unstable
dc.subjectC-reactive protein
dc.subjectCoronary arteriosclerosis
dc.subjectLipoprotein (a)
dc.subjectP-selectin
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleBiomarcadores coronarios y evolución clínica alejada en pacientes con síndromes coronarios agudos sin elevación del segmento ST
dc.title.alternativeCoronary biomarkers and long-term clinical outcome in acute coronary syndrome without ST segment elevation
dc.typeartículo
dc.volumen30
sipa.codpersvinculados85018
sipa.codpersvinculados98700
sipa.codpersvinculados100212
sipa.codpersvinculados81173
sipa.codpersvinculados729
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