Steatotic livers. Can we use them in OLTX? Outcome data from a prospective baseline liver biopsy study

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dc.contributor.authorGabriel, Mauricio
dc.contributor.authorMoisan, Fabrizio
dc.contributor.authorVidal, Marcela
dc.contributor.authorDuarte, Ignacio
dc.contributor.authorJimenez, Macarena
dc.contributor.authorIzquierdo, Guillermo
dc.contributor.authorDominguez, Pilar
dc.contributor.authorMendez, Javier
dc.contributor.authorSoza, Alejandro
dc.contributor.authorBenitez, Carlos
dc.contributor.authorPerez, Rosa
dc.contributor.authorArrese, Marco
dc.contributor.authorGuerra, Juan
dc.contributor.authorJarufe, Nicolas
dc.contributor.authorMartinez, Jorge
dc.date.accessioned2024-01-10T12:43:01Z
dc.date.available2024-01-10T12:43:01Z
dc.date.issued2012
dc.description.abstractIntroduction. Steatotic livers have been associated with greater risk of allograft dysfunction in liver transplantation. Our aim was to determinate the prevalence of steatosis in grafts from deceased donors in Chile and to assess the utility of a protocol-bench biopsy as an outcome predictor of steatotic grafts in our transplant program. Material and methods. We prospectively performed protocol-bench graft biopsies from March 2004 to January 2009. Biopsies were analyzed and classified by two independent pathologists. Steatosis severity was graded as normal from absent to < 6%; grade 1: 6-33%; grade 2: > 33-66% and grade 3: > 66%. Results. We analyzed 58 liver grafts from deceased donors. Twenty-nine grafts (50%) were steatotic; 9 of them (16%) with grade 3. Donor age (p < 0.001) and BMI over 25 kg/m(2) (p = 0.012) were significantly associated with the presence of steatosis. There were two primary non-functions (PNF); both in a grade 3 steatotic graft. The 3-year overall survival was lower among recipients with macrovesicular steatotic graft (57%) than recipients with microvesicular (85%) or non-steatotic grafts (95%) (p = 0.026). Conclusion. Macrovesicular steatosis was associated with a poor outcome in this series. A protocol bench-biopsy would be useful to identify these grafts.
dc.description.funderChilean National Fund for Research in Science and Technology
dc.fechaingreso.objetodigital2024-04-10
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S1665-2681(19)31415-2
dc.identifier.issn1665-2681
dc.identifier.pubmedidMEDLINE:23109453
dc.identifier.urihttps://doi.org/10.1016/S1665-2681(19)31415-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77560
dc.identifier.wosidWOS:000313605300010
dc.information.autorucMedicina;Arrese M ;S/I;76095
dc.information.autorucMedicina;Benitez C ;S/I;9202
dc.information.autorucMedicina;Dominguez P ;S/I;78794
dc.information.autorucMedicina;Duarte I ;S/I;98528
dc.information.autorucMedicina;Gabrielli M ;S/I;199878
dc.information.autorucMedicina;Guerra J ;S/I;159745
dc.information.autorucMedicina;Izquierdo G ;S/I;156225
dc.information.autorucMedicina;Jarufe N;S/I;104492
dc.information.autorucMedicina;Jimenez M;S/I;156223
dc.information.autorucMedicina;Martinez J ;S/I;65778
dc.information.autorucMedicina;Moisan F ;S/I;175122
dc.information.autorucMedicina;Soza A;S/I;461
dc.information.autorucMedicina;Vidal M;S/I;1009089
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final898
dc.pagina.inicio891
dc.publisherMEXICAN ASSOC HEPATOLOGY
dc.revistaANNALS OF HEPATOLOGY
dc.rightsacceso abierto
dc.subjectFatty liver
dc.subjectLiver steatosis
dc.subjectLiver transplantation
dc.subjectOrgan injury
dc.subjectTransplantation
dc.subjectASIA-PACIFIC REGION
dc.subjectFATTY LIVER
dc.subjectHEPATIC STEATOSIS
dc.subjectMARGINAL DONORS
dc.subjectDISEASE
dc.subjectTRANSPLANTATION
dc.subjectCRITERIA
dc.subjectGRAFTS
dc.subjectCOMMON
dc.subjectRISK
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSteatotic livers. Can we use them in OLTX? Outcome data from a prospective baseline liver biopsy study
dc.typeartículo
dc.volumen11
sipa.codpersvinculados76095
sipa.codpersvinculados9202
sipa.codpersvinculados78794
sipa.codpersvinculados98528
sipa.codpersvinculados199878
sipa.codpersvinculados159745
sipa.codpersvinculados156225
sipa.codpersvinculados104492
sipa.codpersvinculados156223
sipa.codpersvinculados65778
sipa.codpersvinculados175122
sipa.codpersvinculados461
sipa.codpersvinculados1009089
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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