A Precision Medicine Guided Approach to the Utilization of Biomarkers in MASLD

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dc.catalogadorjlo
dc.contributor.authorThakral, Nimish
dc.contributor.authorDesalegn, Hailemichael
dc.contributor.authorDiaz Piga, Luis Antonio
dc.contributor.authorCabrera, Daniel
dc.contributor.authorLoomba, Rohit
dc.contributor.authorArrese Jiménez, Marco Antonio
dc.contributor.authorArab Verdugo, Juan Pablo
dc.date.accessioned2024-11-20T12:47:14Z
dc.date.available2024-11-20T12:47:14Z
dc.date.issued2024
dc.description.abstractThe new nomenclature of metabolic dysfunction-associated steatotic liver disease (MASLD) emphasizes a positive diagnosis based on cardiometabolic risk factors. This definition is not only less stigmatizing but also allows for subclassification and stratification, thereby addressing the heterogeneity of what was historically referred to as nonalcoholic fatty liver disease. The heterogeneity within this spectrum is influenced by several factors which include but are not limited to demographic/dietary factors, the amount of alcohol use and drinking patterns, metabolic status, gut microbiome, genetic predisposition together with epigenetic factors. The net effect of this dynamic and intricate system-level interaction is reflected in the phenotypic presentation of MASLD. Therefore, the application of precision medicine in this scenario aims at complex phenotyping with consequent individual risk prediction, development of individualized preventive strategies, and improvements in the clinical trial designs. In this review, we aim to highlight the importance of precision medicine approaches in MASLD, including the use of novel biomarkers of disease, and its subsequent utilization in future study designs.
dc.format.extent14 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1055/a-2364-2928
dc.identifier.urihttps://doi.org/10.1055/a-2364-2928
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88603
dc.information.autorucEscuela de Medicina; Diaz Piga, Luis Antonio; 0000-0002-8540-4930; 179253
dc.information.autorucEscuela de Medicina; Arrese Jiménez, Marco Antonio; 0000-0002-0499-4191; 76095
dc.information.autorucEscuela de Medicina; Arab Verdugo, Juan Pablo; 0000-0002-8561-396X; 132745
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final286
dc.pagina.inicio273
dc.revistaSeminars in Liver Disease
dc.rightsacceso restringido
dc.subjectBiomarkers
dc.subjectSteatosis
dc.subjectMASLD
dc.subjectCirrhosis
dc.subject.ddc610
dc.titleA Precision Medicine Guided Approach to the Utilization of Biomarkers in MASLD
dc.typeartículo
dc.volumen44
sipa.codpersvinculados179253
sipa.codpersvinculados76095
sipa.codpersvinculados132745
sipa.trazabilidadORCID;2024-08-19
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