Prediction of hepatocellular carcinoma response to 90Yttrium radioembolization using volumetric ADC histogram quantification: preliminary results

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dc.contributor.authorGordic, Sonja.
dc.contributor.authorWagner, Mathilde.
dc.contributor.authorZanato, Riccardo.
dc.contributor.authorHectors, Stefanie.
dc.contributor.authorBesa Correa, Cecilia
dc.contributor.authorKihira, Shingo.
dc.contributor.authorKim, Edward.
dc.contributor.authorTaouli, Bachir.
dc.date.accessioned2019-10-17T18:24:17Z
dc.date.available2019-10-17T18:24:17Z
dc.date.issued2019
dc.date.updated2019-10-14T19:14:04Z
dc.description.abstractAbstract Purpose To assess the predictive value of volumetric apparent diffusion coefficient (vADC) histogram quantification obtained before and 6 weeks (6w) post-treatment for assessment of hepatocellular carcinoma (HCC) response to 90Yttrium radioembolization (RE). Methods In this retrospective study, 22 patients (M/F 15/7, mean age 65y) who underwent lobar RE were included between October 2013 and November 2014. All patients underwent routine liver MRI pre-treatment and 6w after RE. Two readers assessed index tumor response at 6 months after RE in consensus, using mRECIST criteria. vADC histogram parameters of index tumors at baseline and 6w, and changes in vADC (ΔvADC) histogram parameters were calculated. The predictive value of ADC metrics was assessed by logistic regression with stepwise parameter selection and ROC analyses. Results Twenty two HCC lesions (mean size 3.9 ± 2.9 cm, range 1.2–12.3 cm) were assessed. Response at 6 months was as follows: complete response (CR, n = 6), partial response (PR, n = 3), stable disease (SD, n = 12) and progression (PD, n = 1). vADC median/mode at 6w (1.81–1.82 vs. 1.29–1.35 × 10− 3 mm2/s) and ΔvADC median/max (27–44% vs. 0–10%) were significantly higher in CR/PR vs. SD/PD (p = 0.011–0.036), while there was no significant difference at baseline. Logistic regression identified vADC median at 6w as an independent predictor of response (CR/PR) with odds ratio (OR) of 3.304 (95% CI: 1.099–9.928, p = 0.033) and AUC of 0.77. ΔvADC mean was identified as an independent predictor of CR with OR of 4.153 (95%CI: 1.229–14.031, p = 0.022) and AUC of 0.91. Conclusion Diffusion histogram parameters obtained at 6w and early changes in ADC from baseline are predictive of subsequent response of HCCs treated with RE, while pre-treatment vADC histogram parameters are not. These results need confirmation in a larger study. Trial registration This retrospective study was IRB-approved and the requirement for informed consent was waived.
dc.fuente.origenBiomed Central
dc.identifier.citationCancer Imaging. 2019 May 29;19(1):29
dc.identifier.doi10.1186/s40644-019-0216-6
dc.identifier.urihttps://doi.org/10.1186/s40644-019-0216-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26854
dc.issue.numeroNo. 29
dc.language.isoen
dc.pagina.final8
dc.pagina.inicio1
dc.revistaCancer Imaginges_ES
dc.rights.holderThe Author(s).
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherCarcinoma hepatocelulares_ES
dc.subject.otherResonancia magnéticaes_ES
dc.subject.otherCáncer - Investigacioneses_ES
dc.titlePrediction of hepatocellular carcinoma response to 90Yttrium radioembolization using volumetric ADC histogram quantification: preliminary resultses_ES
dc.typeartículo
dc.volumenVol. 19
sipa.codpersvinculados167343
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