Part 1: Effect of vitamin C on the biological activity of two euryfurylbenzoquinones on TLT, a murine hepatoma cell line

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dc.contributor.authorBenites, Julio
dc.contributor.authorRojo, Leonel
dc.contributor.authorValderrama, Jaime A.
dc.contributor.authorTaper, Henryk
dc.contributor.authorCalderon, Pedro Buc
dc.date.accessioned2024-01-10T13:51:49Z
dc.date.available2024-01-10T13:51:49Z
dc.date.issued2008
dc.description.abstract2-Euryfuryl- and 2-euryfuryl-3-nitro-1,4-benzoquinone Q2 and Q3, prepared via oxidative coupling reactions of sesquiterpene euryfuran 1 to 2-nitro-1,4-benzoquinone and 1,4-benzoquinone, were tested for their cytotoxicity towards TLT cells (a murine hepatoma cell line) in the absence and in the presence of vitamin C. Their cytotoxic profile was completely different. In cells incubated with Q2 (from 1 to 50 mu g/ml), cell survival was not modified, both GSH and ATP were depleted to about 50% of control values (at 50 mu g/ml); and caspase-3 was activated in a dose-dependent manner. These effects were observed whatever cells were incubated or not in the presence of vitamin C. In the case of Q3, the cytotoxicity was rather unrelated to its concentration but the association of vitamin C plus the highest Q3 concentration (50 mu g/ml) results in a strong cell death (more than 60%). At such a concentration, a complete lack of caspase-3 activity was observed, probably due to cell lysis. At lower concentrations of Q3 (1 and 10 mu g/ml), caspase-3 activity was lower than that observed in the absence of vitamin C or even under control conditions. Both GSH and ATP were kept fairly constant as compared to control values but in the presence of vitamin C and Q3, at 50 mu g/ml, a decrease in their amounts was observed. (C) 2007 Elsevier Masson SAS. All rights reserved.
dc.description.funderDI - UNAP
dc.fechaingreso.objetodigital2024-04-16
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ejmech.2007.11.015
dc.identifier.eissn1768-3254
dc.identifier.issn0223-5234
dc.identifier.pubmedidMEDLINE:18179847
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2007.11.015
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79628
dc.identifier.wosidWOS:000260074200003
dc.information.autorucQuímica;Valderrama J;S/I;98772
dc.issue.numero9
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1817
dc.pagina.inicio1813
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
dc.revistaEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
dc.rightsacceso restringido
dc.subjectVitamin C
dc.subjectEuryfurylbenzoquinones
dc.subjectRedox cycling
dc.subjectReactive oxygen species
dc.subjectCell death
dc.subjectOXIDATIVE STRESS
dc.subjectIN-VITRO
dc.subjectLEUKEMIA-CELLS
dc.subjectASCORBATE
dc.subjectQUINONES
dc.subjectAPOPTOSIS
dc.subjectGROWTH
dc.subjectTUMORS
dc.subjectDEATH
dc.subjectCYTOTOXICITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePart 1: Effect of vitamin C on the biological activity of two euryfurylbenzoquinones on TLT, a murine hepatoma cell line
dc.typeartículo
dc.volumen43
sipa.codpersvinculados98772
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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