Remifentanil Requirements During Sevoflurane Administration to Block Somatic and Cardiovascular Responses to Skin Incision in Children and Adults

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dc.catalogadordfo
dc.contributor.authorMuñoz, Hernán R.
dc.contributor.authorCortínez Fernandéz, Luis Ignacio
dc.contributor.authorAltermatt Couratier, Fernando René
dc.contributor.authorDagnino Sepúlveda, Jorge
dc.date.accessioned2024-08-22T16:23:46Z
dc.date.available2024-08-22T16:23:46Z
dc.date.issued2002
dc.description.abstractBackground: The authors found no studies comparing intraoperative requirements of opioids between children and adults, so they determined the infusion rate of remifentanil to block somatic (IR50) and autonomic response (ERBAR(50)) to skin incision in children and adults.", "Methods: Forty-one adults (aged 20-60 yr) and 24 children (aged 2-10 yr) undergoing lower abdominal surgery were studied. In adults, anesthesia induction was with sevoflurane during remifentanil infusion, whereas in children remifentanil administration was started after induction with sevoflurane. After intubation, sevoflurane was administered in 100% 02 and was adjusted to an ET% of 1 MAC-awake corrected for age at least 15 min before surgery. Patients were randomized to receive remifentanil at a rate ranging from 0.05 to 0.35 mug.kg(-1).min(-1) for at least 20 min before surgery. At the beginning of surgery, only the skin incision was performed, and the somatic and autonomic responses were observed. The somatic response was defined as positive with any gross movement of extremity, and the autonomic response was deemed positive with any increase in heart rate or mean arterial pressure equal to or more than 10% of preincision values. Using logistic regression, the IR50. and IRBAR(50) were determined in both groups of patients and compared with unpaired Student t test. A P value less than 0.05 was considered significant.", "Results: The IR50 +/- SD was 0.10 +/- 0.02 mug.kg(-1).min(-1) in adults and 0.22 +/- 0.03 mug.kg(-1).min(-1) in children (P < 0.001). The IRBAR50 SD was 0.11 &PLUSMN; 0.02 &mu;g.kg(-1).min(-1) in adults and 0.27 &PLUSMN; 0.06 &mu;g.kg(-1).min(-1) in children (P < 0.001).", "Conclusions: To block somatic and autonomic responses to surgery, children require a remifentanil infusion rate at least twofold higher than adults.
dc.description.funderNo tiene
dc.format.extent4 páginas
dc.fuente.origenHistorial Académico
dc.identifier.doi10.1097/00000542-200211000-00018
dc.identifier.eissn1528-1175
dc.identifier.issn0003-3022
dc.identifier.urihttps://doi.org/10.1097/00000542-200211000-00018
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87606
dc.identifier.wosidWOS:000179034600017
dc.information.autorucEscuela de Medicina; Cortinez Fernandez Luis Ignacio; 0000-0001-8544-8768; 79356
dc.information.autorucEscuela de Medicina; Altermatt Couratier Fernando Rene; 0000-0002-0464-8643; 7381
dc.information.autorucEscuela de Medicina; Dagnino Sepulveda Jorge; S/I; 98860
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1145
dc.pagina.inicio1142
dc.revistaAnesthesiology
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleRemifentanil Requirements During Sevoflurane Administration to Block Somatic and Cardiovascular Responses to Skin Incision in Children and Adults
dc.typeartículo
dc.volumen97
sipa.codpersvinculados79356
sipa.codpersvinculados7381
sipa.codpersvinculados98860
sipa.trazabilidadHistorial Académico;09-07-2021
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