Development and validation of an improved classification and risk stratification system for carotid body tumors: A multinational collaborative cohort study

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dc.contributor.authorMehanna, Hisham
dc.contributor.authorMistry, Pankaj
dc.contributor.authorGolusinski, Pawel
dc.contributor.authorMaio, Pasquale Di
dc.contributor.authorNankivell, Paul
dc.contributor.authorSnider, Francesco
dc.contributor.authorFerrante, Angela M. R.
dc.contributor.authorMontalto, Nausica
dc.contributor.authorNicolai, Piero
dc.contributor.authorMarcantoni, Alessandra
dc.contributor.authorGrandi, Cesare
dc.contributor.authorZavatta, Marco
dc.contributor.authorGrego, Franco
dc.contributor.authorMalec, Kataryna
dc.contributor.authorHosal, Sefik
dc.contributor.authorSuslu, Nilda
dc.contributor.authorKuscu, Oguz
dc.contributor.authorTorrealba, Ignacio
dc.contributor.authorValdes, Francisco
dc.contributor.authorSharma, Neil
dc.contributor.authorAyuk, John
dc.contributor.authorMonksfield, Peter
dc.contributor.authorIrving, Richard
dc.contributor.authorDunn, Janet A.
dc.contributor.authorKay, Mark
dc.contributor.authorBorsetto, Daniele
dc.date.accessioned2025-01-20T22:10:27Z
dc.date.available2025-01-20T22:10:27Z
dc.date.issued2021
dc.description.abstractBackground This study aims to develop and validate a new classification system that better predicts combined risk of neurological and neurovascular complications following CBT surgery, crucial for treatment decision-making. Methods Multinational retrospective cohort study with 199 consecutive cases. A cohort of 132 CBT cases was used to develop the new classification. To undertake external validation, assessment was made between the actual complication rate and predicted risk by the model on an independent cohort (n = 67). Results Univariate analyses showed statistically significant associations between developing a complication and the following factors: craniocaudal dimension, volume, Shamblin classification, and Mehanna types. In the multivariate prognostic model, only Mehanna type remained as a significant risk predictor. The risk of developing complications increases with increasing Mehanna type. Conclusions We have developed and then validated a new classification and risk stratification system for CBTs, which demonstrated better prognostic power for the risk of developing neurovascular complications after surgery.
dc.description.funderNational Institute for Health Research (NIHR)
dc.fuente.origenWOS
dc.identifier.doi10.1002/hed.26844
dc.identifier.eissn1097-0347
dc.identifier.issn1043-3074
dc.identifier.urihttps://doi.org/10.1002/hed.26844
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94373
dc.identifier.wosidWOS:000686933100001
dc.issue.numero11
dc.language.isoen
dc.pagina.final3458
dc.pagina.inicio3448
dc.revistaHead and neck-journal for the sciences and specialties of the head and neck
dc.rightsacceso restringido
dc.subjectcarotid body tumor
dc.subjectclassification
dc.subjectparaganglioma
dc.subjectShamblin
dc.subjectsurgery
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDevelopment and validation of an improved classification and risk stratification system for carotid body tumors: A multinational collaborative cohort study
dc.typeartículo
dc.volumen43
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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