Non-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer

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dc.contributor.authorRollan, Antonio
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorGederlini, Alessandra
dc.contributor.authorSerrano, Carolina
dc.contributor.authorTorres, Javiera
dc.contributor.authorHarris, Paul
dc.date.accessioned2024-01-10T12:40:55Z
dc.date.available2024-01-10T12:40:55Z
dc.date.issued2006
dc.description.abstractAIM: To validate a non-invasive method to detect gastric mucosal atrophy in a Chilean population with high prevalence of gastric cancer and a poor survival rate.
dc.description.abstractMETHODS: We first determined the optimal cut-off level of serum pepsinogen (PG)-1, PG-1/PG-2 ratio and 17-gastrin in 31 voluntary symptomatic patients (mean age: 66.1 years), of them 61% had histologically confirmed gastric atrophy. Then, in a population-based sample of 536 healthy individuals (209 residents in counties with higher relative risk and 327 residents in counties with lower relative risk for gastric cancer), we measured serum anti-H pylori antibodies, PG and 17-gastrin and estimated their risk of gastric cancer.
dc.description.abstractRESULTS: We found that serum PG-1 < 61.5 mu g/L, PG-1/PG-2 ratio < 2.2 and 17-gastrin > 13.3 pmol/L had a high specificity (91%-100%) and a fair sensitivity (56%-78%) to detect corpus-predominant atrophy. Based on low serum PG-1 and PG-1/PG-2 ratio together as diagnostic criteria, 12.5% of the asymptomatic subjects had corpus-predominant atrophy (0% of those under 25 years and 20.2% over 65 years old). The frequency of gastric atrophy was similar (12% vs 13%) but H pylori infection rate was slightly higher (77% vs 71%) in the high-risk compared to the low-risk counties. Based on their estimated gastric cancer risk, individuals were classified as: low-risk group (no H pylori infection and no atrophy; n = 115; 21.4%); moderate-risk group (H pylori infection but no atrophy; n = 354, 66.0%); and high-risk group (gastric atrophy, with or without H pylori infection; n = 67, 12.5%). The high-risk group was significantly older (mean age: 61.9 +/- 13.3 years), more frequently men and less educated as compared with the low-risk group.
dc.description.abstractCONCLUSION: We propose to concentrate on an upper gastrointestinal endoscopy for detection of early gastric cancer in the high-risk group. This intervention model could improve the poor prognosis of gastric cancer in Chile. (C) 2006 The WJG Press. All rights reserved.
dc.fechaingreso.objetodigital2024-05-27
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3748/wjg.v12.i44.7172
dc.identifier.eissn2219-2840
dc.identifier.issn1007-9327
dc.identifier.pubmedidMEDLINE:17131482
dc.identifier.urihttps://doi.org/10.3748/wjg.v12.i44.7172
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77362
dc.identifier.wosidWOS:000242527600017
dc.information.autorucMedicina;Ferreccio F;S/I;99684
dc.information.autorucMedicina;Harris P;S/I;80706
dc.issue.numero44
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final7178
dc.pagina.inicio7172
dc.publisherBAISHIDENG PUBLISHING GROUP INC
dc.revistaWORLD JOURNAL OF GASTROENTEROLOGY
dc.rightsacceso abierto
dc.subjectgastric cancer
dc.subjectH pylori
dc.subjectgastric atrophy
dc.subjectnon-invasive diagnosis
dc.subjectpepsinogen
dc.subjectgastrin
dc.subjectSERUM PEPSINOGEN-I
dc.subjectHELICOBACTER-PYLORI INFECTION
dc.subjectPERNICIOUS-ANEMIA
dc.subjectRISK
dc.subjectCHINA
dc.subjectRATIO
dc.subjectMETAANALYSIS
dc.subjectPROGRESSION
dc.subjectANTIBODIES
dc.subjectCARCINOMA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNon-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer
dc.typeartículo
dc.volumen12
sipa.codpersvinculados99684
sipa.codpersvinculados80706
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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