Platelet count/spleen diameter ratio for non-invasive prediction of high risk esophageal varices in cirrhotic patients

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dc.contributor.authorBarrera, Francisco
dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorSoza, Alejandro
dc.contributor.authorContreras, Alvaro
dc.contributor.authorBarrios, Gerty
dc.contributor.authorPadilla, Oslando
dc.contributor.authorViviani, Paola
dc.contributor.authorMaria Perez Ayuso, Rosa
dc.date.accessioned2024-01-10T12:41:32Z
dc.date.available2024-01-10T12:41:32Z
dc.date.issued2009
dc.description.abstractBackground and objective. Prophylaxis therapy is indicated in cirrhotic patients with large esophageal varices or small varices with red wale signs (high risk esophageal varices; HREV). Endoscopic surveillance to detect HREV is currently recommended. The objective of this study is to identify non-invasive predictors of HREV in cirrhotic patients. Design and methods. Adult cirrhotic patients without previous variceal bleeding were prospectively included. All patients underwent a complete biochemical workup, upper digestive endoscopy, and ultrasonographic measurement of spleen bipolar diameter. Platelet count/spleen diameter ratio (PC/SD) was calculated for all patients. The association of these variables with the presence of HREV in upper endoscopy was tested using univariate and multivariate analysis. Receiver operating characteristic (ROC) curves were constructed for variables associated with HREV. Results. Sixty-seven patients were included. The prevalence rate of HREV was 50%. Age, gender (female), platetet count, spleen diameter, PC/SD ratio, total bilirrubin, prothrombin activity (INR), Childl-Pugh score, clinical and ultrasonographic ascites were significantly associated with presence of HREV in univariate analysis. Age and PC/SD ratio were the parameters independently associated with HREV in a multivariate analysis, with OR 8.81 (CI 95%: 1.7-44.9) and OR 11.21 (CI 95%: 2.8-44.6) respectively. A PC/SD ratio cut-off value under 830.8 predicted HREV with 76.9% sensitivity, 74.2% specificity and 77.8% negative predictive value (ROC curve area: 0.78). Conclusions. The PC/SD ratio was significantly associated with HREV, but with suboptimal sensitivity and specificity. Therefore, the results of this study do not support the routine clinical use of PC/SD ratio for screening of HREV.
dc.fechaingreso.objetodigital2024-04-16
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S1665-2681(19)31745-4
dc.identifier.issn1665-2681
dc.identifier.pubmedidMEDLINE:20009131
dc.identifier.urihttps://doi.org/10.1016/S1665-2681(19)31745-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77426
dc.identifier.wosidWOS:000272586100006
dc.information.autorucMedicina;Barrera F;S/I;14816
dc.information.autorucMedicina;Barrios G;S/I;114290
dc.information.autorucMedicina;Contreras A;S/I;17991
dc.information.autorucMatemática;Padilla O;S/I;102063
dc.information.autorucMedicina;Pérez-Ayuso RM;S/I;100479
dc.information.autorucMedicina;Riquelme A;S/I;3538
dc.information.autorucMedicina;Soza A;S/I;461
dc.information.autorucMatemática;Viviani P;S/I;729
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final330
dc.pagina.inicio325
dc.publisherELSEVIER ESPANA
dc.revistaANNALS OF HEPATOLOGY
dc.rightsacceso abierto
dc.subjectEsophageal varices
dc.subjectPortal hypertension
dc.subjectLiver cirrhosis
dc.subjectNon-invasive predictors
dc.subjectPlatelet count
dc.subjectAbdominal ultrasound
dc.subjectPORTAL-HYPERTENSION
dc.subjectLIVER-DISEASE
dc.subjectVALIDATION
dc.subjectDIAGNOSIS
dc.subjectHEMORRHAGE
dc.subjectHISTORY
dc.subjectMODEL
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePlatelet count/spleen diameter ratio for non-invasive prediction of high risk esophageal varices in cirrhotic patients
dc.typeartículo
dc.volumen8
sipa.codpersvinculados14816
sipa.codpersvinculados114290
sipa.codpersvinculados17991
sipa.codpersvinculados102063
sipa.codpersvinculados100479
sipa.codpersvinculados3538
sipa.codpersvinculados461
sipa.codpersvinculados729
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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