Quantitative description of the morphology and ossification center in the axial skeleton of 20-week gestation formalin-fixed human fetuses using magnetic resonance images

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dc.contributor.authorChabert, Steren
dc.contributor.authorVillalobos, Manuel
dc.contributor.authorUlloa, Patricia
dc.contributor.authorSalas, Rodrigo
dc.contributor.authorTejos, Cristian
dc.contributor.authorSan Martin, Sebastian
dc.contributor.authorPereda, Jaime
dc.date.accessioned2024-01-10T12:41:55Z
dc.date.available2024-01-10T12:41:55Z
dc.date.issued2012
dc.description.abstractObjectives Human tissues are usually studied using a series of two-dimensional visualizations of in vivo or cutout specimens. However, there is no precise anatomical description of some of the processes of human fetal development. The purpose of our study is to develop a quantitative description of the normal axial skeleton by means of high-resolution three-dimensional magnetic resonance (MR) images, collected from six normal 20-week-old human fetuses fixed in formaldehyde.
dc.description.abstractMethods Fetuses were collected after spontaneous abortion and subsequently fixed with formalin. They were imaged using a 1.5 T MR scanner with an isotropic spatial resolution of 200 m. The correct tissue discrimination between ossified and cartilaginous bones was confirmed by comparing the images achieved by MR scans and computerized axial tomographies. The vertebral column was segmented out from each image using a specially developed semiautomatic algorithm.
dc.description.abstractResults Vertebral body dimensions and inter-vertebral distances were larger in the lumbar region, in agreement with the beginning of the ossification process from the thoracolumbar region toward the sacral and cephalic ends.
dc.description.abstractConclusion In this article, we demonstrate the feasibility of using MR images to study the ossification process in formalin-fixed fetal tissues. A quantitative description of the ossification centers of vertebral bodies and arches is presented. (C) 2012 John Wiley & Sons, Ltd.
dc.description.funderCONICYT-Fondecyt
dc.description.funderDIPUV
dc.description.funderCONICYT-Anillo
dc.description.funderDIPUV-CI
dc.fechaingreso.objetodigital2024-04-11
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/pd.2942
dc.identifier.eissn1097-0223
dc.identifier.issn0197-3851
dc.identifier.pubmedidMEDLINE:22430723
dc.identifier.urihttps://doi.org/10.1002/pd.2942
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77464
dc.identifier.wosidWOS:000301639300008
dc.information.autorucIngeniería;Tejos C ;S/I;4027
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final258
dc.pagina.inicio252
dc.publisherWILEY
dc.revistaPRENATAL DIAGNOSIS
dc.rightsacceso restringido
dc.subjectfetal MRI
dc.subjectformalin-fixed fetal imaging
dc.subjectaxial skeleton
dc.subjectanatomy
dc.subjectossification
dc.subjectFETAL SPINE
dc.subjectFIXATION
dc.subjectMRI
dc.subjectSPECIMENS
dc.subjectTRIMESTER
dc.subjectGROWTH
dc.subjectBRAIN
dc.subjectSIZE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleQuantitative description of the morphology and ossification center in the axial skeleton of 20-week gestation formalin-fixed human fetuses using magnetic resonance images
dc.typeartículo
dc.volumen32
sipa.codpersvinculados4027
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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