Innate lymphoid cells at the human maternal-fetal interface in spontaneous preterm labor

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dc.contributor.authorXu, Yi
dc.contributor.authorRomero, Roberto
dc.contributor.authorMiller, Derek
dc.contributor.authorSilva, Pablo
dc.contributor.authorPanaitescu, Bogdan
dc.contributor.authorTheis, Kevin R.
dc.contributor.authorArif, Afrah
dc.contributor.authorHassan, Sonia S.
dc.contributor.authorGomez Lopez, Nardhy
dc.date.accessioned2024-01-10T12:39:47Z
dc.date.available2024-01-10T12:39:47Z
dc.date.issued2018
dc.description.abstractProblem: Pathological inflammation is causally linked to preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide. Our aims were to investigate whether (i) the newly described family of innate lymphoid cells (ILCs) was present at the human maternal-fetal interface and (ii) ILC inflammatory subsets were associated with the pathological process of preterm labor.
dc.description.abstractMethods of study: Decidual leukocytes were isolated from women with preterm or term labor as well as from gestational age-matched non-labor controls. ILCs (CD15(-)CD14(-)CD3(-)CD19(-)CD56(-)CD11b(-) CD127(+) cells) and their subsets (ILC1, T-bet+ ILCs; ILC2, GATA3+ ILCs; and ILC3, ROR gamma t+ ILCs) and cytokine expression were identified in the decidual tissues using immunophenotyping.
dc.description.abstractResults: (i) The proportion of total ILCs was increased in the decidua parietalis of women with preterm labor; (ii) ILC1s were a minor subset of decidual ILCs during preterm and term gestations; (iii) ILC2s were the most abundant ILC subset in the decidua during preterm and term gestations; (iv) the proportion of ILC2s was increased in the decidua basalis of women with preterm labor; (v) the proportion of ILC3s was increased in the decidua parietalis of women with preterm labor; and (vi) during preterm labor, ILC3s had higher expression of IL-22, IL-17A, IL-13, and IFN-gamma compared to ILC2s in the decidua.
dc.description.abstractConclusion: ILC2s were the most abundant ILC subset at the human maternal-fetal interface during preterm and term gestations. Yet, during preterm labor, an increase in ILC2s and ILC3s was observed in the decidua basalis and decidua parietalis, respectively. These findings provide evidence demonstrating a role for ILCs at the maternal-fetal interface during the pathological process of preterm labor.
dc.description.funderEunice Kennedy Shriver National Institute of Child Health and Human Development
dc.description.funderNICHD/NIH/DHHS
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.fechaingreso.objetodigital2024-05-28
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/aji.12820
dc.identifier.eissn1600-0897
dc.identifier.issn1046-7408
dc.identifier.pubmedidMEDLINE:29457302
dc.identifier.urihttps://doi.org/10.1111/aji.12820
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77234
dc.identifier.wosidWOS:000431964500003
dc.information.autorucCiencias de la Salud;Silva P ;S/I;1067208
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherWILEY
dc.revistaAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
dc.rightsacceso restringido
dc.subjectcytokine
dc.subjectdecidua
dc.subjectinflammation
dc.subjectinnate immunity
dc.subjectinterleukin
dc.subjectmucosal immunity
dc.subjectparturition
dc.subjectpregnancy
dc.subjecttolerance
dc.subjectNATURAL-KILLER-CELLS
dc.subjectAMNIOTIC-FLUID INTERLEUKIN-6
dc.subjectROR-GAMMA-T
dc.subjectINTRAAMNIOTIC INFLAMMATION
dc.subjectCLINICAL-SIGNIFICANCE
dc.subjectMICROBIAL INVASION
dc.subjectPREMATURE RUPTURE
dc.subjectUREAPLASMA-UREALYTICUM
dc.subjectGESTATIONAL-AGE
dc.subjectINFECTION
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleInnate lymphoid cells at the human maternal-fetal interface in spontaneous preterm labor
dc.typeartículo
dc.volumen79
sipa.codpersvinculados1067208
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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