Maternal and perinatal outcomes related to COVID-19 and pregnancy: An overview of systematic reviews

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dc.catalogadorgjm
dc.contributor.authorVergara-Merino, Laura
dc.contributor.authorMeza, Nicolás
dc.contributor.authorCouve-Pérez, Constanza
dc.contributor.authorCarrasco, Cynthia
dc.contributor.authorOrtiz Muñoz, Luis Eugenio
dc.contributor.authorMadrid, Eva
dc.contributor.authorBohorquez-Blanco, Sandra
dc.contributor.authorBracchiglione, Javier
dc.date.accessioned2024-06-28T12:57:41Z
dc.date.available2024-06-28T12:57:41Z
dc.date.issued2021
dc.description.abstractIntroduction: Evidence about coronavirus disease 2019 (COVID-19) and pregnancy has rapidly increased since December 2019, making it difficult to make rigorous evidence-based decisions. The objective of this overview of systematic reviews is to conduct a comprehensive analysis of the current evidence on prognosis of COVID-19 in pregnant women. Material and methods: We used the Living OVerview of Evidence (L·OVE) platform for COVID-19, which continually retrieves studies from 46 data sources (including PubMed/MEDLINE, Embase, other electronic databases, clinical trials registries, and preprint repositories, among other sources relevant to COVID-19), mapping them into PICO (population, intervention, control, and outcomes) questions. The search covered the period from the inception date of each database to 13 September 2020. We included systematic reviews assessing outcomes of pregnant women with COVID-19 and/or their newborns. Two authors independently screened the titles and abstracts, assessed full texts to select the studies that met the inclusion criteria, extracted data, and appraised the risk of bias of each included systematic review. We measured the overlap of primary studies included among the selected systematic reviews by building a matrix of evidence, calculating the corrected covered area, and assessing the level of overlap for every pair of systematic reviews. Results: Our search yielded 1132 references. 52 systematic reviews met inclusion criteria and were included in this overview. Only one review had a low risk of bias, three had an unclear risk of bias, and 48 had a high risk of bias. Most of the included reviews were highly overlapped among each other. In the included reviews, rates of maternal death varied from 0% to 11.1%, admission to intensive care from 2.1% to 28.5%, preterm deliveries before 37 weeks from 14.3% to 61.2%, and cesarean delivery from 48.3% to 100%. Regarding neonatal outcomes, neonatal death varied from 0% to 11.7% and the estimated infection status of the newborn varied between 0% and 11.5%. Conclusions: Only one of 52 systematic reviews had a low risk of bias. Results were heterogeneous and the overlap of primary studies was frequently very high between pairs of systematic reviews. High-quality evidence syntheses of comparative studies are needed to guide future clinical decisions.
dc.fuente.origenORCID
dc.identifier.doi10.1111/aogs.14118
dc.identifier.eissn1600-0412
dc.identifier.pubmedid33560530
dc.identifier.scopusidSCOPUS_ID:85103923801
dc.identifier.urihttps://doi.org/10.1111/aogs.14118
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86901
dc.identifier.wosidWOS:000636038200001
dc.information.autorucEscuela de Medicina; Ortiz Muñoz, Luis Eugenio; S/I; 121678
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1218
dc.pagina.inicio1200
dc.revistaActa Obstetricia et Gynecologica Scandinavica
dc.rightsacceso restringido
dc.subjectCoronavirus disease 2019
dc.subjectCoronavirus infections
dc.subjectInfant
dc.subjectNewborn
dc.subjectOverview
dc.subjectPregnant women
dc.subjectSystematic reviews as topic
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMaternal and perinatal outcomes related to COVID-19 and pregnancy: An overview of systematic reviews
dc.typeartículo de revisión
dc.volumen100
sipa.codpersvinculados121678
sipa.trazabilidadORCID;2024-06-24
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