Pediatric Ischemic Stroke: An Infrequent Complication of SARS-CoV-2

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dc.contributor.authorBeslow, Lauren A.
dc.contributor.authorLinds, Alexandra B.
dc.contributor.authorDlamini N.
dc.contributor.authorFox, Christine K.
dc.contributor.authorKossorotoff, Manoëlle
dc.contributor.authorZuñiga Zambrano, Yenny C.
dc.contributor.authorHernández Chavez, Marta Isabel
dc.contributor.authorHassanein, Sahar .M.A.
dc.contributor.authorByrne, Susan
dc.contributor.authorLim, Ming
dc.contributor.authorMaduaka, Nkechi
dc.contributor.authorZafeiriou, Dimitrios
dc.contributor.authorDowling, Michael M.
dc.contributor.authorFelling, Ryan J.
dc.contributor.authorRafay, Mubeen F.
dc.contributor.authorLehman, Laura L.
dc.contributor.authorNoetzel, Michael J.
dc.contributor.authorBernard, Timothy J.
dc.contributor.authorDlamini, Nomazulu
dc.contributor.otherInternational Pediatric Stroke Study Group
dc.date.accessioned2024-01-10T14:22:43Z
dc.date.available2024-01-10T14:22:43Z
dc.date.issued2021
dc.description.abstract© 2020 American Neurological AssociationObjective: Severe complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include arterial ischemic stroke (AIS) in adults and multisystem inflammatory syndrome in children. Whether stroke is a frequent complication of pediatric SARS-CoV-2 is unknown. This study aimed to determine the proportion of pediatric SARS-CoV-2 cases with ischemic stroke and the proportion of incident pediatric strokes with SARS-CoV-2 in the first 3 months of the pandemic in an international cohort. Methods: We surveyed 61 international sites with pediatric stroke expertise. Survey questions included: numbers of hospitalized pediatric (≤ 18 years) patients with SARS-CoV-2; numbers of incident neonatal and childhood ischemic strokes; frequency of SARS-CoV-2 testing for pediatric patients with stroke; and numbers of stroke cases positive for SARS-CoV-2 from March 1 to May 31, 2020. Results: Of 42 centers with SARS-CoV-2 hospitalization numbers, 8 of 971 (0.82%) pediatric patients with SARS-CoV-2 had ischemic strokes. Proportions of stroke cases positive for SARS-CoV-2 from March to May 2020 were: 1 of 108 with neonatal AIS (0.9%), 0 of 33 with neonatal cerebral sinovenous thrombosis (CSVT; 0%), 6 of 166 with childhood AIS (3.6%), and 1 of 54 with childhood CSVT (1.9%). However, only 30.5% of neonates and 60% of children with strokes were tested for SARS-CoV-2. Therefore, these proportions represent 2.9, 0, 6.1, and 3.0% of stroke cases tested for SARS-CoV-2. Seven of 8 patients with SARS-CoV-2 had additional established stroke risk factors. Interpretation: As in adults, pediatric stroke is an infrequent complication of SARS-CoV-2, and SARS-CoV-2 was detected in only 4.6% of pediatric patients with ischemic stroke tested for the virus. However, < 50% of strokes were tested. To understand the role of SARS-CoV-2 in pediatric stroke better, SARS-CoV-2 testing should be considered in pediatric patients with stroke as the pandemic continues. ANN NEUROL 2021;89:657–665.
dc.fechaingreso.objetodigital03-04-2024
dc.fuente.origenScopus
dc.identifier.doi10.1002/ana.25991
dc.identifier.eissn15318249
dc.identifier.issn15318249 03645134
dc.identifier.pubmedid33332607
dc.identifier.scopusidSCOPUS_ID:85099906288
dc.identifier.urihttps://doi.org/10.1002/ana.25991
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79989
dc.identifier.wosidWOS:000612581600001
dc.information.autorucEscuela de Medicina; Hernandez Chavez Marta Isabel; 0000-0002-4238-8969; 55673
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final665
dc.pagina.inicio657
dc.publisherJohn Wiley and Sons Inc
dc.revistaAnnals of Neurology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePediatric Ischemic Stroke: An Infrequent Complication of SARS-CoV-2
dc.typeartículo
dc.volumen89
sipa.codpersvinculados55673
sipa.indexWos
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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