The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A

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dc.contributor.authorRivas, Solange
dc.contributor.authorArmisen, Ricardo
dc.contributor.authorRojas, Diego A.
dc.contributor.authorMaldonado, Edio
dc.contributor.authorHuerta, Hernan
dc.contributor.authorTapia, Julio C.
dc.contributor.authorEspinoza, Jaime
dc.contributor.authorColombo, Alicia
dc.contributor.authorMichea, Luis
dc.contributor.authorHayman, Michael J.
dc.contributor.authorMarcelain, Katherine
dc.date.accessioned2024-01-10T13:43:56Z
dc.date.available2024-01-10T13:43:56Z
dc.date.issued2016
dc.description.abstractOncogenic kinase Aurora A (AURKA) has been found to be overexpresed in several tumors including colorectal, breast, and hematological cancers. Overexpression of AURKA induces centrosome amplification and aneuploidy and it is related with cancer progression and poor prognosis. Here we show that AURKA phosphorylates in vitro the transcripcional co-repressor Ski on aminoacids Ser326 and Ser383. Phosphorylations on these aminoacids decreased Ski protein half-life. Reduced levels of Ski resulted in centrosomes amplification and multipolar spindles formation, same as AURKA overexpressing cells. Importantly, overexpression of Ski wild type, but not S326D and S383D mutants inhibited centrosome amplification and cellular transformation induced by AURKA. Altogether, these results suggest that the Ski protein is a target in the transformation pathway mediated by the AURKA oncogene. (C) 2015 Wiley Periodicals, Inc.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico
dc.description.funderU.S. Public Health Service Grant
dc.description.funderNATIONAL CANCER INSTITUTE
dc.fechaingreso.objetodigital2024-04-27
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/jcb.25275
dc.identifier.eissn1097-4644
dc.identifier.issn0730-2312
dc.identifier.pubmedidMEDLINE:26138431
dc.identifier.urihttps://doi.org/10.1002/jcb.25275
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78796
dc.identifier.wosidWOS:000368229900007
dc.information.autorucMedicina; Espinoza J;S/I;237746
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final343
dc.pagina.inicio334
dc.publisherWILEY
dc.revistaJOURNAL OF CELLULAR BIOCHEMISTRY
dc.rightsacceso restringido
dc.subjectSki
dc.subjectAURKA
dc.subjectAURORA KINASE
dc.subjectCENTROSOME AMPLIFICATION
dc.subjectPROMOTES TUMOR-GROWTH
dc.subjectC-SKI
dc.subjectPANCREATIC-CANCER
dc.subjectTGF-BETA
dc.subjectCHROMOSOMAL INSTABILITY
dc.subjectCOLORECTAL-CANCER
dc.subjectHUMAN-MELANOMA
dc.subjectCELL-LINES
dc.subjectIN-VIVO
dc.subjectEXPRESSION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A
dc.typeartículo
dc.volumen117
sipa.codpersvinculados237746
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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