Allelic Variants of Melanocortin 3 Receptor Gene (MC3R) and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets

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dc.contributor.authorSantos, Jose L.
dc.contributor.authorDe la Cruz, Rolando
dc.contributor.authorHolst, Claus
dc.contributor.authorGrau, Katrine
dc.contributor.authorNaranjo, Carolina
dc.contributor.authorMaiz, Alberto
dc.contributor.authorAstrup, Arne
dc.contributor.authorSaris, Wim H. M.
dc.contributor.authorMacDonald, Ian
dc.contributor.authorOppert, Jean Michel
dc.contributor.authorHansen, Torben
dc.contributor.authorPedersen, Oluf
dc.contributor.authorSorensen, Thorkild I. A.
dc.contributor.authorAlfredo Martinez, J.
dc.contributor.authorNUGENOB Consortium
dc.date.accessioned2024-01-10T12:37:30Z
dc.date.available2024-01-10T12:37:30Z
dc.date.issued2011
dc.description.abstractIntroduction: The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets.
dc.description.abstractSubjects and Methods: This research is based on the NUGENOB study, a trial conducted to assess weight loss during a 10-week dietary intervention involving two different hypo-energetic (high-fat and low-fat) diets. A total of 760 obese patients were genotyped for 10 single nucleotide polymorphisms covering the single exon of MC3R gene and its flanking regions, including the missense variants Thr6Lys and Val81Ile. Linear mixed models and haplotype-based analysis were carried out to assess the potential association between genetic polymorphisms and differential weight loss, fat mass loss, waist change and resting energy expenditure changes.
dc.description.abstractResults: No differences in drop-out rate were found by MC3R genotypes. The rs6014646 polymorphism was significantly associated with weight loss using co-dominant (p = 0.04) and dominant models (p = 0.03). These p-values were not statistically significant after strict control for multiple testing. Haplotype-based multivariate analysis using permutations showed that rs3827103-rs1543873 (p = 0.06), rs6014646-rs6024730 (p = 0.05) and rs3746619-rs3827103 (p = 0.10) displayed near-statistical significant results in relation to weight loss. No other significant associations or gene*diet interactions were detected for weight loss, fat mass loss, waist change and resting energy expenditure changes.
dc.description.abstractConclusion: The study provided overall sufficient evidence to support that there is no major effect of genetic variants of MC3R and differential weight loss after a 10-week dietary intervention with hypo-energetic diets in obese Europeans.
dc.description.funderEU
dc.description.funderLinea Especial de la Universidad de Navarra
dc.description.funderChilean FONDECYT
dc.description.funderEuropean Community
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1371/journal.pone.0019934
dc.identifier.issn1932-6203
dc.identifier.pubmedidMEDLINE:21695122
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0019934
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76861
dc.identifier.wosidWOS:000291682300002
dc.information.autorucMedicina;De la Cruz R ;S/I;119
dc.information.autorucMedicina;Maiz A ;S/I;23935
dc.information.autorucMedicina;Santos J ;S/I;1005923
dc.issue.numero6
dc.language.isoen
dc.nota.accesoSin adjunto
dc.publisherPUBLIC LIBRARY SCIENCE
dc.revistaPLOS ONE
dc.rightsregistro bibliográfico
dc.subjectGENOME-WIDE ASSOCIATION
dc.subjectCHILDHOOD OBESITY
dc.subjectEATING BEHAVIOR
dc.subjectFOOD-INTAKE
dc.subjectBODY-FAT
dc.subjectPOLYMORPHISMS
dc.subjectINSULIN
dc.subjectMOUSE
dc.subjectINDIVIDUALS
dc.subjectMUTATIONS
dc.subject.ods03 Good Health and Well-being
dc.subject.ods02 Zero Hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleAllelic Variants of Melanocortin 3 Receptor Gene (MC3R) and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets
dc.typeartículo
dc.volumen6
sipa.codpersvinculados119
sipa.codpersvinculados23935
sipa.codpersvinculados1005923
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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